Male Breast Cancer Presenting as Nipple Discharge

Farooq, Ansar; Horgan, K.

doi:10.1155/2011/804843

Cited by 3 publications

(7 citation statements)

References 21 publications

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“…Cytology of ND has not been reported to be conclusive, as the cellularity can be the issue . In our cases, ND cytology was helpful in establishing a papillary lesion and interestingly the cellularity was lower in case 2 having copious discharge.…”

Section: Discussionmentioning

confidence: 58%

“…There are very few reports describing ND, as a presenting feature, in cases of male breast cancer (MBC) . Other causes of ND can be duct papilloma, duct ectasia, fibrocystic change, gynaecomastia, and even skin adnexal tumors . Evaluation of ND can be very helpful, especially when positive …”

Section: Introductionmentioning

confidence: 99%

“…Males presenting with nipple discharge (ND) is very uncommon. There are very few reports describing ND, as a presenting feature, in cases of male breast cancer (MBC) . Other causes of ND can be duct papilloma, duct ectasia, fibrocystic change, gynaecomastia, and even skin adnexal tumors .…”

Section: Introductionmentioning

confidence: 99%

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Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum

Sood

2018

Diagnostic Cytopathology

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Nipple discharge (ND) either in the presence or in the absence of underlying mass is a very uncommon presentation in males and its bloody nature is still rarer. ND cytology in males has not been reported much in the literature. Spontaneous and expressed ND, however, can be very useful in establishing the diagnosis. Two males with bloody ND, one, without any palpable mass and another with underlying mass, were evaluated on ND cytology. The presence of loose papillaroid clusters and cell sheets with mild atypia was seen in ND smears itself in case 1. The discharge was more copious in case 2, but the ND smears were paucicellular. The presence of tall columnar cells in ND smears as well as in the FNA from underlying mass with clear features of malignancy was helpful in reaching the diagnosis of papillary carcinoma in case 2. Histopathology in case 1 was a spectrum of ADH to DCIS, whereas in case 2, was tubulopapillary carcinoma.Following two cases highlight the importance of the cytological evaluation of ND smears. K E Y W O R D S carcinoma, nipple discharge, papillaroid, papillary DCIS 1 | INTRODUCTION Males presenting with nipple discharge (ND) is very uncommon. There are very few reports describing ND, as a presenting feature, in cases of male breast cancer (MBC). 1,2 Other causes of ND can be duct papilloma, duct ectasia, fibrocystic change, gynaecomastia, and even skin adnexal tumors. 1 Evaluation of ND can be very helpful, especially when positive. 3,4 As there is limited data available on ND evaluation, in males, any new cases need to be recorded and added to the literature for a better understanding of this subject. 2 | CASE REPORTS 2.1 | Case 1 A 70-year-old male presented with unilateral bloody ND off and on. On examination, it was spontaneous and appeared to come from the central duct of left nipple. No mass lesion was found. The smears from the spontaneous ND showed papillaroid clusters of epithelial cells, without significant atypia, in a haemorrhagic background. Further squeesing yielded very cellular smears, comprising of monolayered sheets of epithelial cells and tiny papillaroid clusters with focal moderate atypia. Dyscohesive atypical epithelial cells were also present (Figure 1). It was reported as papillary lesion with atypical ductal hyperplasia and was advised radiological examination, and guided trucut biopsy. However, the surgeons performed a microdochotomy and the specimen showed four tiny foci of grey-white areas, ranging from 3 to 6 mm. No grossly dilated duct could be identified. Sections showed multiple foci of spectrum of ADH to DCIS (cribriform, solid, and papillary) and were ER, PR positive (Figure 2). No invasive carcinoma could be identified. Subsequently, the patient underwent mastectomy, which showed only benign rudimentary ducts embedded in adipose tissue and scant stroma without any significant proliferation. | Case 2A 62-year-old male presented with copious bloody ND off and on with painless enlargement of right breast. On examination, it was spontaneous and appeared to be multi...

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum

Sood

2018

Diagnostic Cytopathology

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“…5 Other causes include papillomata, which are rarely found in men, gynecomastia, or skin cancer located in the periareolar region. 6 Retroareolar breast abscess can develop as a reaction to infection or to the presence of foreign bodies. We hypothesize that the patient's nipple was innoculated by the eggs of Musca domestica either through the Montgomery glands or the terminal ducts and therefore caused a foreign body-type reaction.…”

Section: Discussionmentioning

confidence: 99%

“…5 Other causes include papillomata, which are rarely found in men, gynecomastia, or skin cancer located in the periareolar region. 6…”

Section: Discussionmentioning

confidence: 99%

Larvae of Musca domestica (common house fly) found intraoperatively in a male breast abscess

Kangas-Dick

Bornstein

Azar

et al. 2020

SAGE Open Medical Case Reports

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A 62-year-old male with type 2 diabetes mellitus presented to our nationally accredited breast center with bilateral breast masses present for 7 years and new-onset pink nipple discharge for several months. Mammography and ultrasound demonstrated a left 2.7 retroareolar cystic lesion and a right 2.1 cm retroareolar solid lesion. Given the suspicious nature of the bilateral breast discharge, core needle biopsies were performed to rule out underlying malignancy. The biopsies revealed benign results, but the discordance between the biopsy, imaging, and suspicious discharge led to the decision to perform bilateral excisional biopsies. Intraoperatively, a small organism resembling a larva was encountered. The abnormal tissue was sent for histopathological examination, along with the organism, which was identified as the larvae of Musca domestica, or common house fly.

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