MALDI‐TOFMS analysis of coordination and organometallic complexes: a nic(h)e area to work in

Wyatt, Mark F.

doi:10.1002/jms.1957

Cited by 31 publications

(25 citation statements)

References 95 publications

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“…68 The applications of MALDI for offline analysis of a variety of small molecule and biological processes are legion, and these studies are too numerous to review here. Instead, we will focus on the development and specific use of MALDI as a tool to intercept reaction intermediates and study mechanism.…”

Section: Methodsmentioning

confidence: 99%

Going beyond electrospray: mass spectrometric studies of chemical reactions in and on liquids

2016

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Section: Methodsmentioning

confidence: 99%

Going beyond electrospray: mass spectrometric studies of chemical reactions in and on liquids

2016

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“…It is based on the detection of the intact molecular ion as gas ionic species, which sometimes is quite hard to get from organometallic compounds . Several ionization techniques have been attempted for the analysis of these complexes by MS . However, most of those trials showed disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometry of rhenium complexes: a comparative study by using LDI‐MS, MALDI‐MS, PESI‐MS and ESI‐MS

et al. 2012

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A group of rhenium (I) complexes including in their structure ligands such as CF(3)SO(3)-, CH(3)CO(2)-, CO, 2,2'-bipyridine, dipyridil[3,2-a:2'3'-c]phenazine, naphthalene-2-carboxylate, anthracene-9-carboxylate, pyrene-1-carboxylate and 1,10-phenanthroline have been studied for the first time by mass spectrometry. The probe electrospray ionization (PESI) is a technique based on electrospray ionization (ESI) that generates electrospray from the tip of a solid metal needle. In this work, mass spectra for organometallic complexes obtained by PESI were compared with those obtained by classical ESI and high flow rate electrospray ionization assisted by corona discharge (HF-ESI-CD), an ideal method to avoid decomposition of the complexes and to induce their oxidation to yield intact molecular cation radicals in gas state [M](+·) and to produce their reduction yielding the gas species [M](-·). It was found that both techniques showed in general the intact molecular ions of the organometallics studied and provided additional structure characteristic diagnostic fragments. As the rhenium complexes studied in the present work showed strong absorption in the UV-visible region, particularly at 355 nm, laser desorption ionization (LDI) mass spectrometry experiments could be conducted. Although intact molecular ions could be detected in a few cases, LDI mass spectra showed diagnostic fragments for characterization of the complexes structure. Furthermore, matrix-assisted laser desorption ionization (MALDI) mass spectra were obtained. Nor-harmane, a compound with basic character, was used as matrix, and the intact molecular ions were detected in two examples, in negative ion mode as the [M](-·) species. Results obtained with 2-[(2E)-3-(4-tert-buthylphenyl)-2-methylprop-2-enylidene] malononitrile (DCTB) as matrix are also described. LDI experiments provided more information about the rhenium complex structures than did the MALDI ones.

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“…As a consequence of LDI or MALDI ionization in the condensed phase, the majority of complexes gave simple and interpretable mass spectra (Wyatt, Stein, and Brenton 2006;Wyatt 2011). However, direct photochemical degradation and other photochemical reactions in course of LDI and MALDI ionization reduced the abundance of molecular ions in favor of fragments.…”

Section: Introductionmentioning

confidence: 98%

Characterization of Rhenium(V) Complexes with Phenols Using Mass Spectrometry with Selected Soft Ionization Techniques

et al. 2015

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The synthesis, characterization, and mass spectra of oxorhenium(V) complexes with 1,2-dihydroxybenzene, 1,2,3-trihydroxybenzene, and 2,3-dihydroxynaphtalene are reported. Electrospray ionization, atmospheric pressure photoionization, and laser desorption/ ionization mass spectra of the complexes showed abundant negatively charged molecular anions and low fragmentation. Calculated similarity indexes showed significant conformity between the computed and experimental isotopic patterns of selected ions and confirmed correct assignment of elemental composition to m/z values. Electrospray tandem mass spectrometry provided essential information about fragments from molecular ions of studied complexes, making it possible to distinguish among fragment ions and the ions arising from compounds present in the reaction mixture. Based on the results, mass spectrometry utilizing soft common ionization techniques is useful for monitoring complex formation reaction kinetics and the stabilities of the complexes. Representative spectra were recorded for micromolar concentrations of the analytes.

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MALDI‐TOFMS analysis of coordination and organometallic complexes: a nic(h)e area to work in

Cited by 31 publications

References 95 publications

Going beyond electrospray: mass spectrometric studies of chemical reactions in and on liquids

Going beyond electrospray: mass spectrometric studies of chemical reactions in and on liquids

Mass spectrometry of rhenium complexes: a comparative study by using LDI‐MS, MALDI‐MS, PESI‐MS and ESI‐MS

Characterization of Rhenium(V) Complexes with Phenols Using Mass Spectrometry with Selected Soft Ionization Techniques

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