MALDI-TOF MS in Anaerobiospirillum succiniciproducens bacteremia: A report of 4 cases in different hosts

Fox, Barbara J.; Berger, María Alejandra; Roncallo, M.; Pinoche, L.; Ibáñez, María Eugenia Pachón; González-Fraga, Sol; Fernández-Canigia, Liliana

doi:10.1016/j.anaerobe.2018.04.003

Cited by 8 publications

(6 citation statements)

References 10 publications

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“…Fusobacteria was reported to be linked with colon cancer [ 44 ]. The genus Anaerobiospirillum consists of Anaerobiospirillum thomasii and Anaerobiospirillum succiniciproducens , which can cause infectious human diseases, such as bacteremia and abdominal infection [ 45 , 46 ]. Previous studies show that the genus Negativibacillus is associated with intestinal disorders and many other diseases such as obesity-related disorders and pediatric Crohn’s disease [ 47 , 48 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Peptides Relieve Transportation Stress in Ragdoll Cats by Regulating the Gut Microbiota

Yang

Wen

et al. 2023

Metabolites

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Transportation is common in cats and often causes stress and intestinal disorders. Antimicrobial peptides (AMPs) exhibit a broad spectrum of antibacterial activity, and they may have the capacity for antioxidant and immune regulation. The objective of this study was to investigate the effects of dietary supplementation with AMPs on stress response, gut microbiota and metabolites of cats that have undergone transport stress. A total of 14 Ragdoll cats were randomly allocated into 2 treatments: basal diet (CON) and a basal diet supplemented with 0.3% AMPs. After a 6-week feeding period, all cats were transported for 3 h and, then, fed for another week. The results show that the diarrhea rate of cats was markedly reduced by supplementation with AMPs throughout the trial period (p < 0.05). In addition, AMPs significantly reduced serum cortisol and serum amyloid A (p < 0.05) and increased apolipoprotein 1 after transportation (p < 0.05). Moreover, AMPs reduced the level of inflammatory factors in the serum caused by transportation stress, including tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) (p < 0.05). The AMPs enhanced the activities of glutathione peroxidase (p < 0.01) and superoxide dismutase (p < 0.05). Furthermore, cats fed AMPs had higher levels of branched chain fatty acids (BCFAs) and a relative abundance of Blautia and a lower relative abundance of Negativibacillus after transportation (p < 0.05). The serum metabolome analysis further revealed that AMPs markedly regulated lipid metabolism by upregulating cholic acid expression. In conclusion, AMP supplementation alleviated oxidative stress and inflammatory response in transportation by regulating the gut microbiota and metabolites, thereby relieving stress-induced diarrhea and supporting gut and host health in cats.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Peptides Relieve Transportation Stress in Ragdoll Cats by Regulating the Gut Microbiota

Yang

Wen

et al. 2023

Metabolites

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“…It has also been described as a cause of knee prosthesis infection [8]. Most infections occur in patients with comorbidities, ethylism or immunosuppression, however, as in the presented case it can also cause infection in immunocompetent patients [6][7][8][9][10]. Although the incidence of these infections is low, mortality is around 25-30% of cases, therefore, rapid action is essential [6,8].…”

mentioning

confidence: 96%

“…Around 50-60 human infections caused by A. succiniproducens have been described, being bacteremia or gastrointestinal infections the most frequent cases [ 6 , 7 ]. It has also been described as a cause of knee prosthesis infection [ 8 ].…”

mentioning

confidence: 99%

“…For all these reasons, identification by MALDI-TOF mass spectrometry is a very important diagnostic tool, since it is a fast and accurate method that has been previously tested for the identification of A. succiniciproducens [ 6 , 7 ]. In addition, direct identification of the blood culture by MALDI-TOF makes the process even faster, being useful in the identification of potentially fatal and growth-demanding organisms such as Capnocytophaga canimorsus [ 11 ] While 16S ribosomal RNA gene sequencing is a more accurate method of identification, it is also more complicated, laborious and takes longer to arrive at identification.…”

mentioning

confidence: 99%

“…In fact, since Fox B et al . conducted their study in 2018 the Bruker MALDI-TOF database has been updated and includes now the main spectra of A. succiniciproducens [ 7 ].…”

mentioning

confidence: 99%

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