MALDI PSD of low molecular weight ethoxylated polymers

Hanton, Scott D.; Parees, David M.; Owens, Kevin G.

doi:10.1016/j.ijms.2004.09.028

Cited by 17 publications

(17 citation statements)

References 22 publications

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“…Figure 3 shows the product ion mass spectrum generated from the m/z 689 [M ϩ Na ϩ ] ϩ ion of the 10 EO telomer. We see the same two fragmentation series observed for PSD of this ion [10]. The more intense series begins at m/z 479.…”

Section: Resultssupporting

confidence: 75%

“…We see these major and minor fragment series for all of the S4XX analytes studied. The description of the assignments and mechanisms for these fragment series is described elsewhere, [10] but the Ϫ210 u series has the mass EO m ϩ O ϩ Na ϩ , and the Ϫ60 u series corresponds to the loss of a mass equivalent to EO m ϩ O. The primary results of the CID experiment match the primary results of the previous PSD experiments, but the data quality is much higher for the CID experiment.…”

Section: Resultsmentioning

confidence: 93%

“…Vacuum MALDI TOFMS experiments have already characterized the molecular weight distributions, chemical composition, and PSD of S4XX surfactants [10,18]. AP MALDI can also generate meaningful mass spectra for these materials.…”

Section: Resultsmentioning

confidence: 99%

“…One of the objectives of these experiments was to investigate the chemical structure of the Ϫ161 u ions observed in the PSD experiments [10]. Unfortunately, no Ϫ161 u ions were observed in any of the product ion mass spectra.…”

Section: Resultsmentioning

confidence: 99%

“…Due to the limitations of volatility, only the low degree of ethoxylation telomers can be studied by GC. In recent vacuum MALDI PSD experiments on S4XX analytes, we attempted to extend the study of these asymmetric telomers [10]. The MALDI PSD experiments produced intense fragments spaced by 44 u.…”

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The fragmentation of ethoxylated surfactants by AP-MALDI-QIT

Hanton

Parees

Zweigenbaum

2006

J. Am. Soc. Mass Spectrom.

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Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has become an important technique to characterize the chemical structure of industrial polymer materials. MALDI methods have been developed to address a broad variety of different polymer materials containing different chemistries. One of the key aspects of the typical MALDI experiment is the generation of intact ions. The development of Atmospheric Pressure (AP) MALDI quadrupole ion trap (QIT) instruments has opened another channel to obtaining MS/MS experiments for polymer samples. These experiments provide a new method to obtain chemical structure information from MALDI experiments. Collision-Induced Dissociation (CID) provides an improved MALDI MS/MS experiment that can be done on readily available mass spectrometers. AP MALDI QIT techniques have been successfully applied to a variety of synthetic polymers. This work explores the applicability of AP MALDI QIT methods to relatively low molecular weight ethoxylated surfactants. In these experiments we show the CID fragmentation mass spectra on some ethoxylated surfactants, and demonstrate the existence of analyte matrix clusters. [5][6][7]. MALDI can generate important data on the telomer repeat units, end groups, and average molecular weights of these materials. MALDI methods have been developed to address a broad variety of different polymer materials containing different chemistries. One of the key aspects of the typical MALDI experiment is the generation of intact ions. MALDI mass spectra generally show little fragmentation. The production of intact ions is vital for the quantitation of average molecular weights, but limits the amount of chemical structural information that can be obtained from the data.The development of MALDI post-source decay (PSD) techniques has opened a new method to obtain chemical structure information from MALDI experiments [8 -10]. Unfortunately, PSD experiments are relatively crude MS/MS experiments. The range of masses submitted for the fragmentation is broad, the mass resolution and mass accuracy of the fragment spectra is not as good as the MALDI data, and there is very limited control of the energy deposition into the fragmentation process.The development of atmospheric pressure (AP) MALDI instruments has enabled the utilization of different mass analyzers for MALDI [11,12]., One of the key benefits to changing the mass analyzer in a MALDI experiment is to significantly improve the MS/MS capability. A quadrupole ion trap (QIT) mass spectrometer is an excellent choice in this regard. Some early work showed examples of high quality MS/MS experiments on MALDI generated peptides [13][14][15][16]. The ability to analyze synthetic polymers using AP MALDI methods on a QIT have also been demonstrated [17].With a QIT mass spectrometer we can accomplish high quality collision-induced dissociation (CID) MS/ MS. The instrument is capable of selecting an individual ion from the mass spectrum for fragmentation. The fragmentation gas and relative energy can be controlled...

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Section: Resultssupporting

confidence: 75%

Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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