MALDI-MSI of lipids in a model of breast cancer brain metastasis provides a surrogate measure of ischemia/hypoxia

Roux, Aurélie; Winnard, Paul T.; Voss, Marise Heerma Van; Muller, Ludovic; Jackson, Shelley N.; Hoffer, Barry J.; Woods, Amina S.; Raman, Venu

doi:10.1007/s11010-023-04685-4

Cited by 3 publications

(4 citation statements)

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“…25 This feature represents a key advantage in mass spectrometry, where different imaging modalities can be used in a complementary fashion since molecules display different propensities for ionization. 26,27 The vast majority of MSI studies involve mapping the distribution of therapeutics and biomolecules, including lipids, [28][29][30] proteins, [31][32][33] peptides, 34 carbohydrates, 35,36 and other metabolites. 37 Biomolecules display heterogeneity; both across different classes of molecules and within subclasses.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative mass spectrometry imaging: therapeutics & biomolecules

Holbrook,

Kemper,

Hummon

2024

Chem. Commun.

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Section: Introductionmentioning

confidence: 99%

“…The vast majority of MSI studies involve mapping the distribution of therapeutics and biomolecules, including lipids, 28–30 proteins, 31–33 peptides, 34 carbohydrates, 35,36 and other metabolites. 37…”

Section: Introductionmentioning

confidence: 99%

Quantitative mass spectrometry imaging: therapeutics & biomolecules

Holbrook,

Kemper,

Hummon

2024

Chem. Commun.

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“…Examples of MALDI-MSI of metabolite distributions in cancer include glioblastoma, 5 thyroid cancer subtypes, 16 pancreatic ductal adenocarcinoma, 17 prostate cancer and breast cancer brain metastasis. 18 MALDI-MSI of metabolites is typically performed in negative ion mode using the matrices 9-aminoacridine (9-AA), diaminonaphthalene (DAN) and N-(1-naphthyl) ethylenediamine dihydrochloride (NEDC). 19 However, analyte coverage is oen limited by varied and oen low ionisation efficiencies of analytes (as low as 10 −9 ), an effect further compounded by the complex nature of biological samples that leads to ion suppression.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancing metabolite coverage in MALDI-MSI using laser post-ionisation (MALDI-2)

Mckinnon¹,

Milioli²,

Purcell³

et al. 2023

Anal. Methods

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Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention

Llorente,

Loughran,

Emerling

2023

Front. Cell Dev. Biol.

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Phosphoinositides serve as essential players in numerous biological activities and are critical for overall cellular function. Due to their complex chemical structures, localization, and low abundance, current challenges in the phosphoinositide field include the accurate measurement and identification of specific variants, particularly those with acyl chains. Researchers are intensively developing innovative techniques and approaches to address these challenges and advance our understanding of the impact of phosphoinositide signaling on cellular biology. This article provides an overview of recent advances in the study of phosphoinositides, including mass spectrometry, lipid biosensors, and real-time activity assays using fluorometric sensors. These methodologies have proven instrumental for a comprehensive exploration of the cellular distribution and dynamics of phosphoinositides and have shed light on the growing significance of these lipids in human health and various pathological processes, including cancer. To illustrate the importance of phosphoinositide signaling in disease, this perspective also highlights the role of a family of lipid kinases named phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks), which have recently emerged as exciting therapeutic targets for cancer treatment. The ongoing exploration of phosphoinositide signaling not only deepens our understanding of cellular biology but also holds promise for novel interventions in cancer therapy.

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MALDI-MSI of lipids in a model of breast cancer brain metastasis provides a surrogate measure of ischemia/hypoxia

Cited by 3 publications

References 50 publications

Quantitative mass spectrometry imaging: therapeutics & biomolecules

Quantitative mass spectrometry imaging: therapeutics & biomolecules

Enhancing metabolite coverage in MALDI-MSI using laser post-ionisation (MALDI-2)

Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention

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