Malathion induced cancer-linked gene expression in human lymphocytes

Anjitha, Ramakrishnan; Antony, Anet; Olakkaran, Shilpa; Anupama, Kizhakke Purayil; Mallikarjunaiah, Shanthala; Gurushankara, Hunasanahally Puttaswamygowda

doi:10.1016/j.envres.2020.109131

Cited by 31 publications

(13 citation statements)

References 87 publications

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“…Despite the unsuitable condition, both disposable gloves were considered in this study due to their widespread by non-occupational handlers of agricultural pesticides 17 . The selection of malathion as a representative pesticide is based on its widespread usage in agricultural sectors and potential toxicological effects on human health 54 , 55 . Malathion, chemically named as diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate, is an organophosphate pesticide used to eradicate pests of gardens, crops, ectoparasites on animals and in public health pest-elimination programs 54 , 56 .…”

Section: Discussionmentioning

confidence: 99%

“…The selection of malathion as a representative pesticide is based on its widespread usage in agricultural sectors and potential toxicological effects on human health 54 , 55 . Malathion, chemically named as diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate, is an organophosphate pesticide used to eradicate pests of gardens, crops, ectoparasites on animals and in public health pest-elimination programs 54 , 56 . However, malathion exposure can potentially induce toxic effects on human health, such as disturbance in metabolism levels, lower acetylcholinesterase activities, neurotoxicity, immunotoxicity and oxidative stress in human lymphocytes 56 , 57 .…”

Section: Discussionmentioning

confidence: 99%

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Assessing the suitability of self-healing rubber glove for safe handling of pesticides

Supramaniam

Low

Wong

et al. 2022

Sci Rep

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Rubber gloves used for protection against chemicals or hazards are generally prone to tearing or leaking after repeated use, exposing the worker to potentially hazardous agents. Self-healing technology promises increased product durability and shelf life appears to be a feasible solution to address these issues. Herein, we aimed to fabricate a novel epoxidized natural rubber-based self-healable glove (SH glove) and investigate its suitability for handling pesticides safely. In this study, breakthrough time analysis and surface morphological observation were performed to determine the SH glove’s ability to withstand dangerous chemicals. The chemical resistance performance of the fabricated SH glove was compared against four different types of commercial gloves at different temperatures. Using malathion as a model pesticide, the results showed that the SH glove presented chemical resistance ability comparable to those gloves made with nitrile and NR latex at room temperature and 37 °C. The self-healing test revealed that the SH glove could be self-healed and retained its chemical resistance ability close to its pre-cut value. Our findings suggested that the developed SH glove with proven chemical resistance capability could be a new suitable safety glove for effectively handling pesticides and reducing glove waste generation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessing the suitability of self-healing rubber glove for safe handling of pesticides

Supramaniam

Low

Wong

et al. 2022

Sci Rep

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“…A recent study has shown that in the presence of Malathion, the initiation and progression of cancer have been correlated with an increase in genomic instability and therefore the formation of tumors in animals, and signs of carcinogenesis in vitro [71]. Moreover, about 57 cancer-associated genes related to the growth and differentiation of B and T cells, immunoglobulin production, tumor suppression, and oncogenes were induced by Malathion [72].…”

Section: Discussionmentioning

confidence: 99%

Farmers’ Knowledge, Attitudes, and Perceptions Regarding Carcinogenic Pesticides in Fez Meknes Region (Morocco)

Khadda

Fagroud

Karmoudi

et al. 2021

IJERPH

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Pesticides play an important role in the improvement of agricultural production, but their use may result in adverse effects on the environment, consumers, and farmers’ health. As there are limited data focusing on the factors influencing safety behavior toward pesticide use in Morocco, we conducted a cross-sectional survey in 15 rural communities of Morocco’s Fes Meknes region to assess the attitudes, knowledge, and practices regarding pesticide use. A structured questionnaire was completed, containing the data of the interviewed farmers, their behavior towards safety measures, the type of active ingredient used, as well as the perception of risks to their own health following exposure to pesticides by the existence of chronic, self-perceived symptoms. Non-probability (empirical) sampling with the quota method was carried out, which consists of constructing the sample. Results showed that most respondents have not been trained in the application of pesticides, with almost half of the farmers using a category of pesticides which are classified by the International Agency for Research on Cancer as probable human carcinogenic (i.e., Glyphosate, Malathion). In terms of pesticide storage, 40% of farmers said that they did not store pesticides in a separate room after purchasing or using them. The empty containers were buried or burnt by half of the responders, while the remainder were thrown at the edge of fields or in public dumps. Although the participants were aware of the negative effects on their own health and on the environment caused by the application of pesticides in use, the protection measures by individual equipment were insufficient. A canonical analysis indicates that these behaviors were influenced by the farming experience, the benefit of the agricultural council services, the follow-up of training, and the education level. These variables are important factors in explaining and understanding the dangers to both the environment and health caused by pesticides. The most recorded likely consequences of pesticide exposure were visual impairment (46%), followed by dizziness (44.3%), headache (39.4%), and excessive sweating (34.4%), and 30.2% of participants identified consequent respiratory problems. Extension services targeted at safety and protection measures should be developed and accompanied by educational programs to put farmers’ perceptions into practice and encourage them to adopt healthy and environmentally friendly behaviors.

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“…MAL was also found to modify gene expression, which also plays a role in carcinogenicity, e.g., it was found to suppress proapoptotic Bax in breast tissues (Omran and Omer 2015). Recently, Anjitha et al found that MAL upregulated or downregulated about 600 and 3500 genes in human lymphocytes, and about 57 of these genes are implicated in the etiology of cancer, such as genes involved in cell growth and differentiation, oncogenes, and signal transduction pathways like MAPK and RAS (Anjitha et al 2020).…”

Section: Mutagenic and Carcinogenic Potentialmentioning

confidence: 99%

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Badr

2020

Environ Sci Pollut Res

102

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Organophosphorus insecticides toxicity is still considered a major global health problem. Malathion is one of the most commonly used organophosphates nowadays, as being considered to possess relatively low toxicity compared with other organophosphates. However, widespread use may lead to excessive exposure from multiple sources. Mechanisms of MAL toxicity include inhibition of acetylcholinesterase enzyme, change of oxidants/antioxidants balance, DNA damage, and facilitation of apoptotic cell damage. Exposure to malathion has been associated with different toxicities that nearly affect every single organ in our bodies, with CNS toxicity being the most well documented. Malathion toxic effects on liver, kidney, testis, ovaries, lung, pancreas, and blood were also reported. Moreover, malathion was considered as a genotoxic and carcinogenic chemical compound. Evidence exists for adverse effects associated with prenatal and postnatal exposure in both animals and humans. This review summarizes the toxic data available about malathion in mammals and discusses new potential therapeutic modalities, with the aim to highlight the importance of increasing awareness about its potential risk and reevaluation of the allowed daily exposure level.

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Malathion induced cancer-linked gene expression in human lymphocytes

Cited by 31 publications

References 87 publications

Assessing the suitability of self-healing rubber glove for safe handling of pesticides

Assessing the suitability of self-healing rubber glove for safe handling of pesticides

Farmers’ Knowledge, Attitudes, and Perceptions Regarding Carcinogenic Pesticides in Fez Meknes Region (Morocco)

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

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