Malathion alters the transcription of target genes of the tumour suppressor tp53 and cancerous processes in Colossoma macropomum: Mechanisms of DNA damage response, oxidative stress and apoptosis

Souza, Samara Silva de; Costa, Jaqueline Custódio da; Silva, Grazyelle Sebrenski da; Almeida-Val, Vera Maria Fonseca de

doi:10.1016/j.cbi.2023.110405

Cited by 2 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hif-1 gene showed an increase in expression, but the Ras (a proto-oncogene) was unaffected. The continuation of this condition downregulated BCL2 levels, and the BCL2/bax ratio resulted in an apoptotic response ( de Souza et al, 2023 ). In grass carp ( Ctenopharyngodon idellus ), the neonicotinoid chemical imidacloprid (IMI), which is commonly used in agricultural production, induced mitochondrial dysfunction, which led to inflammation and an increase in NF-kB, TNF, IL-1, and IL-6 (pro-inflammatory genes) expression.…”

Section: Pesticides Induced Oxidative Stress In Fishesmentioning

confidence: 99%

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Subaramaniyam,

Allimuthu,

Vappu

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially on fish. Fish is a staple and affordable food source, rich in animal protein, along with various vitamins, essential amino acids, and minerals. Exposure of fish to microplastics, pesticides, and various nanoparticles generates ROS and induces oxidative stress, inflammation, immunotoxicity, genotoxicity, and DNA damage and alters gut microbiota, thus reducing the growth and quality of fish. Changes in fish behavioral patterns, swimming, and feeding habits were also observed under exposures to the above contaminants. These contaminants also affect the Nrf-2, JNK, ERK, NF-κB, and MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes in fish. Effects of pesticides, microplastics, and nanoparticles found to modulate many antioxidant enzymes, including superoxide dismutase, catalase, and glutathione system. So, to protect fish health from stress, the contribution of nano-technology or nano-formulations was researched. A decrease in fish nutritional quality and population significantly impacts on the human diet, influencing traditions and economics worldwide. On the other hand, traces of microplastics and pesticides in the habitat water can enter humans by consuming contaminated fish which may result in serious health hazards. This review summarizes the oxidative stress caused due to microplastics, pesticides and nano-particle contamination or exposure in fish habitat water and their impact on human health. As a rescue mechanism, the use of nano-technology in the management of fish health and disease was discussed.

show abstract

Section: Pesticides Induced Oxidative Stress In Fishesmentioning

confidence: 99%

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Subaramaniyam,

Allimuthu,

Vappu

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Oxidative damage is intricately linked to the occurrence and progression of tumors [ 16 ]. Free radicals presented in intracellular and extracellular environments can promote the development of cancer cells via the introduction of genetic mutations, and regulate tumor cell proliferation and apoptosis by influencing the various signaling pathways [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Yu,

Long,

Chi

et al. 2024

Nutrients

View full text Add to dashboard Cite

Ethanol fractional precipitation can initially separate polysaccharides according to the structure, which exhibits strong correlation with the biological activities. This study aimed to investigate the impact of varying ethanol concentrations on the structural characteristics, and the antitumor and antioxidant activities of polysaccharides derived from Dendrobium officinale through ethanol fractional precipitation, as well as their internal relationships. The polysaccharides acquired by absolute alcohol additions at a final liquor-ethanol volume ratio of 1:1, 1:2, and 1:4 were named DOP-1, DOP-2, and DOP-4, and the supernatant was named DOP-S. The results of the structural analysis revealed that the increase in ethanol concentrations resulted in a reduction in the molecular weights and the acetylation degree of the polysaccharides, as well as a decrease in mannose content and an increase in glucose content. In vitro experiments demonstrated that DOP-S exhibited optimal antitumor and antioxidant activities. Animal experiments further confirmed that DOP-S suppressed the growth of solid tumors significantly, enhanced lymphocytes, mediated immune ability, and improved the activity of antioxidant enzymes. These findings would establish a theoretical foundation and provide technical support for further advances and applications of polysaccharides derived from D. officinale in the fields of food and medicine.

show abstract

Malathion alters the transcription of target genes of the tumour suppressor tp53 and cancerous processes in Colossoma macropomum: Mechanisms of DNA damage response, oxidative stress and apoptosis

Cited by 2 publications

References 50 publications

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Contact Info

Product

Resources

About