2020
DOI: 10.1016/j.cellsig.2020.109676
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MALAT1 overexpression promotes the growth of colon cancer by repressing β-catenin degradation

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Cited by 14 publications
(11 citation statements)
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“…These results indicated significant changes in the level of pro-inflammatory oncogenic cytokine (IL-6), antioxidant enzyme (SOD1), a pro-transcription activator of Wnt signaling cascade (β-catenin), and the dynamic tumor transcription factor (NF-κB). There was a high correlation between the overexpression of the potential prognostic factor, β-catenin, and the progression of colorectal cancer from normal epithelial tissue, polyps, and adenomas to carcinomas in colorectal cancer patients 12 13 and levels of SOD and IL-6 were closely related to cancer risk. 14 15 The results confirmed that oral intake of low doses-BaP caused harmful effects by inducing DNA adducts by increasing the inflammation (i.e., IL-6) and oxidative stress (i.e., SOD1) in the stomach and colon.…”
Section: Discussionmentioning
confidence: 97%
“…These results indicated significant changes in the level of pro-inflammatory oncogenic cytokine (IL-6), antioxidant enzyme (SOD1), a pro-transcription activator of Wnt signaling cascade (β-catenin), and the dynamic tumor transcription factor (NF-κB). There was a high correlation between the overexpression of the potential prognostic factor, β-catenin, and the progression of colorectal cancer from normal epithelial tissue, polyps, and adenomas to carcinomas in colorectal cancer patients 12 13 and levels of SOD and IL-6 were closely related to cancer risk. 14 15 The results confirmed that oral intake of low doses-BaP caused harmful effects by inducing DNA adducts by increasing the inflammation (i.e., IL-6) and oxidative stress (i.e., SOD1) in the stomach and colon.…”
Section: Discussionmentioning
confidence: 97%
“…In addition, Co-IP as well as protein stability and degradation assays revealed the relationship between TRIM50 and β -catenin. A published study by Zheng et al found that inhibiting β -catenin degradation can promote the development of colon cancer [ 35 ]. Moreover, suppression of the Wnt/ β -catenin pathway in GC cells by treatment with XAV939 obviously inhibited TRIM50 knockdown-induced cell proliferation, cycle progression, migration, invasion and the expression of the Wnt/ β -cateninpathway-related proteins.…”
Section: Discussionmentioning
confidence: 99%
“…MALAT1 is overexpressed in many types of cancer (Goyal et al 2021 ), including CRCs (Younis et al 2022 ; Uthman et al 2021 ; Hu et al 2021 ; Zheng et al 2020 ; Xiong et al 2018 ; Yang et al 2015 ), metastatic lung cancers (Shen et al 2015 ), advanced stages of pancreatic cancers (Pang et al 2015 ). In general, high levels of MALAT1 expression have been demonstrated in the vast majority of CRC specimens compared to adjacent non-tumor control colorectal tissue specimens in cancer patients (Sun et al 2019b ; Zheng et al 2020 ; Luan et al 2020 ; Xiong et al 2018 ; Li et al 2017a ). Moreover, MALAT1 expression was significantly higher in advanced stages III–IV of tumor-node-metastasis (TNM) (Labianca et al 2013 ) than in early stages I–II of CRC (Luan et al 2020 ).…”
Section: Malat1 and Other Lncrnas Affecting The Level Of Ty...mentioning
confidence: 99%