Malassezia responds to environmental pH signals through the conserved Rim/Pal pathway
Kaila M. Pianalto,
Calla L. Telzrow,
Hannah Brown Harding
et al.
Abstract:During mammalian colonization and infection, microorganisms must be able to rapidly sense and adapt to changing environmental conditions including alterations in extracellular pH. The fungus-specific Rim/Pal signaling pathway is one process that supports microbial adaptation to alkaline pH. This cascading series of interacting proteins terminates in the proteolytic activation of the highly conserved Rim101/PacC protein, a transcription factor that mediates microbial responses that favor survival in neutral/alk… Show more
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