Malaria vaccines

Quagliata, Michael; Papini, Anna Maria; Rovero, Paolo

doi:10.1080/13543776.2023.2190884

Cited by 7 publications

(2 citation statements)

References 63 publications

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“…Previous in silico and in vitro studies have shown that both ligands or peptides binding at the spike ACE2–RBD and interacting with Tyr505, Arg403, Lys417, His42, Glu37, Asn33 and Arg393 can potentially block viral cell entry. 24,31–33…”

Section: Resultsmentioning

confidence: 99%

Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD–ACE2 and TMPRRS2 proteins

Shayo,

Samwel,

Shadrack

et al. 2024

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD–ACE2 and TMPRRS2 proteins

Shayo,

Samwel,

Shadrack

et al. 2024

RSC Adv.

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“…In a randomised, phase 3 trial among children aged 5–36 months followed for 24 months, R21/Matrix-M™ prevented 75% of malaria episodes, and there was a 77% reduction in multiple malaria episodes in the vaccinated group compared to the control group in children from sites with seasonal malaria transmission [ 6 ]. Unless pre-erythrocytic stage malaria vaccines confer sterile immunity, developing effective blood-stage malaria vaccines and identifying blood-stage antigen vaccine candidates to complement pre-erythrocytic stage malaria vaccines in multi-antigen/multi-stage malaria vaccines [ 7 ] is crucial to eliminating the burden of malaria.…”

Section: Introductionmentioning

confidence: 99%

Antibody-Dependent Respiratory Burst against Plasmodium falciparum Merozoites in Individuals Living in an Area with Declining Malaria Transmission

Mutemi,

Tuju,

Ogwang

et al. 2024

Vaccines

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Malaria transmission intensity affects the development of naturally acquired immunity to malaria. An absolute correlate measure of protection against malaria is lacking. However, antibody-mediated functions against Plasmodium falciparum correlate with protection against malaria. In children, antibody-mediated functions against P. falciparum decline with reduced exposure. It is unclear whether adults maintain antibody-mediated functions as malaria transmission declines. This study assessed antibody-dependent respiratory burst (ADRB) in individuals from an area with declining malaria transmission. In an age-matched analysis, we compare ADRB activity during high versus low malaria transmission periods. Age significantly predicted higher ADRB activity in the high (p < 0.001) and low (p < 0.001) malaria transmission periods. ADRB activity was higher during the high compared to the low malaria transmission period in older children and adults. Only older adults during the high malaria transmission period had their median ADRB activity above the ADRB cut-off. Ongoing P. falciparum infection influenced ADRB activity during the low (p = 0.01) but not the high (p = 0.29) malaria transmission period. These findings propose that naturally acquired immunity to P. falciparum is affected in children and adults as malaria transmission declines, implying that vaccines will be necessary to induce and maintain protection against malaria.

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Review on cerebral malaria—Pathogenesis and role of EphA2 receptor in maintaining blood brain barrier integrity

Shaikh,

Baig,

Ali

et al. 2024

Health Sciences Review

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Malaria vaccines

Cited by 7 publications

References 63 publications

Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD–ACE2 and TMPRRS2 proteins

Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD–ACE2 and TMPRRS2 proteins

Antibody-Dependent Respiratory Burst against Plasmodium falciparum Merozoites in Individuals Living in an Area with Declining Malaria Transmission

Review on cerebral malaria—Pathogenesis and role of EphA2 receptor in maintaining blood brain barrier integrity

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