Malaria Pre-elimination Assessment in Eastern Indonesia

More than half of the areas in East Nusa Tenggara province, a province in the eastern part of Indonesia, are planned to be free from malaria by the end of 2030. However, one of the critical indicators for malaria elimination is still lacking, i.e. vectors’ environment and breeding place indicators. South Central Timor (SCT) District is one of the areas with the highest Annual Parasite Incidence (API) >2‰ with the majority of the population works as farmers. The purpose of this study was to capture the relationship between environmental factors and the prevalence of malaria. This study was a cross-sectional analytic retrospective study using data from a previous malaria study conducted in August 2013 to September 2014 in 5 sub-districts of SCT district. All respondents were selected using the systematic random sampling approach from the population of healthy people. Data were collected using a standard questionnaire and an observation environment form. Malaria was confirmed through microscopic and Polymerase Chain Reaction (PCR) examinations. Data were then analyzed using the bivariate and multivariate analysis with 95% CI and α:0.05. Of 357 data collected, 35% (125/357) were malaria positive based on PCR examination. Two variables (living nearby lagoon and nearby rice field) were significant (p-value<0.05) as vector shelters for Anopheles sp. Thus, these have to be included as inputs to formulate effective and efficient malaria elimination strategies and programs in 2030.

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Potential Vector Shelter for Malaria in South Central Timor Regency in Indonesia

Fauziah

Mohamad

Nugraha

et al. 2020

mkb

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Malaria Situation in The South Kalimantan Province, 2010–2018

Ridha¹,

Kasman

Liani³

et al. 2021

JBE

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Background: Malaria has caused high morbidity and mortality rates and has decreased the productivity of human resources and national development. Malaria is endemic in several districts in South Kalimantan. Purpose: This study aims to describe the malaria situation in South Kalimantan by examining the malaria cases, Case Fatality Rate (CFR), Annual Parasite Incidence (API), and Slide Parasite Rate (SPR) in the South Kalimantan Province during the period of 2010–2018. Method: This research was a descriptive study with the South Kalimantan population, who were at risk of getting malaria. This study adopted a total participation technique and included all the cases of malaria recorded in the electronic- Surveillance Information System of Malaria (e-SISMAL) data of South Kalimantan province in the period 2010–2018. The study used secondary data from the South Kalimantan Provincial Health Office during 2010–2018. The data included the number of malaria cases, morbidity, and the mortality rate of malaria. The data collected was analyzed using CFR, API, and the SPR formulae. Results: The number of malaria cases in South Kalimantan from 2010 to 2018 fluctuated. The highest number of malaria cases occurred in 2011, while a decreasing trend was observed up to 2018. At the same time, the number of deaths during 2012–2018 increased. The death rate from 2010–2018 decreased in South Kalimantan. Conclusion: The number of cases as well as deaths caused due to malaria in South Kalimantan continues to decrease. By 2025, all districts in South Kalimantan could be free from malaria.

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Prevalence of Glucose 6-Phosphate Dehydrogenase Variants in Malaria-Endemic Areas of South Central Timor, Eastern Indonesia

Sulistyaningrum

Arlinda

Hutagalung

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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Primaquine is an effective anti-hypnozoite drug for Plasmodium vivax and Plasmodium ovale. However, it can trigger erythrocyte hemolysis in people with glucose 6-phosphate dehydrogenase (G6PD) deficiency. In a previous report from South Central Timor (SCT), Indonesia, we described the prevalence of Vanua Lava, Chatham, and Viangchan variants; in this study, other G6PD variants (Kaiping, Coimbra, Gaohe, Canton, and Mahidol) were subsequently analyzed. For clarity, all of these results are described together. The 381 DNA samples from the previous study during 2013-2014 were analyzed for G6PD variants by using PCR-restriction fragment length polymorphism (RFLP). The prevalence of G6PD deficiency in SCT was 6.3% (24/381 cases), including 4.2% (16/381 cases), 0.5% (2/381 cases), and 1.6% (6/381 cases) for Coimbra, Kaiping, and Vanua Lava variants, respectively. No other variants were found in this population. A significant association was found between ethnicity and the distribution of G6PD Kaiping in female subjects. A positive association was shown between G6PD activity and heterozygous females carrying Coimbra genotype, hemizygous males carrying Vanua Lava, Plasmodium falciparum infection in female subjects, and P. vivax infection in male subjects. Further molecular analysis of heterozygous females, particularly in malaria-endemic areas, is needed for mapping distribution of G6PD deficiency status in Indonesia.

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Malaria Pre-elimination Assessment in Eastern Indonesia

Cited by 3 publications

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Potential Vector Shelter for Malaria in South Central Timor Regency in Indonesia

Potential Vector Shelter for Malaria in South Central Timor Regency in Indonesia

Malaria Situation in The South Kalimantan Province, 2010–2018

Prevalence of Glucose 6-Phosphate Dehydrogenase Variants in Malaria-Endemic Areas of South Central Timor, Eastern Indonesia

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