Malaria in Children

Kafai, Natasha M.; John, Audrey Odom

doi:10.1016/j.idc.2017.10.008

Cited by 18 publications

(29 citation statements)

References 43 publications

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“…However, RDT specificity was nil. This again raises the false positive issues with RDTs as discussed above [3]. The persistence of the HRP2 antigen sometimes until two weeks after treatment may explained these false positives results with RDTs [2].…”

Section: Discussionmentioning

confidence: 92%

“…Likewise, both false-positive and false-negative results have been reported with RDTs worldwide [2,3]. Thus, polymerase chain reaction (PCR) for malaria remains the gold standard for diagnostic confirmation and species identification, with the highest sensitivity and specificity [3]. However, in our context of lack of such testing in our routine, the diagnosis is based on RDT before confirmation by the microscopic detection on peripheral blood sample of erythrocytic forms of Plasmodium by thick and thin blood films examination with a result obtained within a maximum of 2 hours [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…However, in many peripheral health facilities of endemic countries, microscopy is not available due to lack of trained microscopists on staff at all times. Likewise, both false-positive and false-negative results have been reported with RDTs worldwide [2,3]. Thus, polymerase chain reaction (PCR) for malaria remains the gold standard for diagnostic confirmation and species identification, with the highest sensitivity and specificity [3].…”

Section: Introductionmentioning

confidence: 99%

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Acute Renal Failure Related to Malaria in Admitted Patients in Pediatric Hospitals from Dakar, Senegal: A Series of Eleven Cases

Diongue

Ndongo

Thiam

et al. 2020

AJPR

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Aims: To firstly determine the incidence of acute renal failure (ARF) related to malaria in a series of 11 cases among admitted patients at the pediatric hospitals in Dakar, Senegal and to lastly measure the performance of rapid diagnostic test (RDT) and microscopy in malaria diagnosis using polymerase chain reaction (PCR) as a gold standard. Study Design: A bi-centric and descriptive study was carried out. Place and Duration of Study: From June 2018 to January 2019 in two university hospitals of Dakar, Senegal: Aristide Le Dantec university hospital and Albert Royer university hospital. Methodology: Pediatric patients aged under 18 years with confirmed malaria by RDT or microscopy and ARF defined by anuria or oligo-anuria and a decrease in glomerular filtration rate were included. Nested PCR was performed to confirm malaria diagnosis and Plasmodium species typing. Results: In total, 11 ARF cases (8.5%) related to malaria among 130 children infected with malaria parasites were included out of 4,474 hospitalized. Affected children were aged between 2 and 16 years with a mean age of 11 years and a sex ratio of 0.57. For malaria diagnosis, RDTs were positive for all patients while microscopy only revealed 6 cases (54.5%) as well as PCR. However, microscopy and PCR presented two discrepancies. Considering PCR as the gold standard tool, RDT showed a relative high sensitivity (100%) and zero specificity with a positive predictive value (PPV) of 54.6% while microscopy respectively showed a sensitivity and a specificity of 66.7 and 60%. Conclusion: This study showed the relatedness between ARF and P. falciparum malaria. Even though microscopy remains the gold standard for the diagnosis of malaria but microscopists must be regularly trained. In addition, RDT should always be confirmed by microscopy and preferably by PCR.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute Renal Failure Related to Malaria in Admitted Patients in Pediatric Hospitals from Dakar, Senegal: A Series of Eleven Cases

Diongue

Ndongo

Thiam

et al. 2020

AJPR

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“…Even though potentially lethal, actually, it is preventable and curable. [1][2][3] During 2018, a rough estimation counts 228 million cases of malaria worldwide. The estimated number of malaria related morbidity as many as 405 000 in 2018.…”

Section: Introductionmentioning

confidence: 99%

“…2 Children and pregnant women are among the most vulnerable group. 3,4 tuberculosis etc made the problem become more complex to solve. 11,12 In Indonesia, due to its wide geographical coverage and the lack of documentation or publication, the study of malaria related anemia has somewhat typically underreported, belatedly, rarely and not thoroughly; even though that the result still give an excellent information needed not just by the academics and the clinicians, but to even to tourism practitioner, because some of Indonesia's best tourism destination located in region considered to be malaria endemic.…”

Section: Introductionmentioning

confidence: 99%

A literature study of anemia among malaria cases reported in Indonesia, from west to east: a parasito-epidemiology perspective

Siagian

2020

Int J Community Med Public Health

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Severe malarial anemia (SMA) is a potentially fatal complication of malaria, a neglected parasitic tropical disease that still become a global health problem. It occurs predominantly in vulnerable groups in the community, especially children and pregnant women living in endemic areas, including Indonesia. The data on prevalence of SMA and its contributing factors are sparse and incomplete, so the aim of this simple literature study is to provide that data. The author doing the electronic literature searching on Indonesia’s data concerning malaria related anemia and factors that might contribute or causing this complication. There are 37 studies found on this issue, from 2001 until 2019. All 37 studies reported that anemia that developed during the course of the disease (malaria) varies from asymptomatic to severe form. This study showed the condition of anemia related malaria in Indonesia, from 2001-2019. Malaria still a big parasito-epidemiology problem. Prevention by continuous health promotion and proper management of malaria should be conducted to eradicate malaria and its complication.

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Infections That Affect the Kidney (Nonviral)

Iyengar

Koch

2022

Pediatric Nephrology

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Malaria in Children

Cited by 18 publications

References 43 publications

Acute Renal Failure Related to Malaria in Admitted Patients in Pediatric Hospitals from Dakar, Senegal: A Series of Eleven Cases

Acute Renal Failure Related to Malaria in Admitted Patients in Pediatric Hospitals from Dakar, Senegal: A Series of Eleven Cases

A literature study of anemia among malaria cases reported in Indonesia, from west to east: a parasito-epidemiology perspective

Infections That Affect the Kidney (Nonviral)

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