Malaria en Chile: 1913 - 2001

F, Hugo Schenone; N., Andrea Olea; S, Antonio Rojas; D, Nolberto García

doi:10.4067/s0034-98872002001000013

Cited by 13 publications

(14 citation statements)

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“…Chile has been certified as a malaria-free country by the World Health Organization (WHO), with no indigenously-acquired cases reported since 1945 [ 8 ]. This was possible due to the implementation of an anti-malaria campaign in the early 1940s directed towards vector ( Anopheles pseudopunctipennis ) control and the prompt treatment of malaria patients [ 8 ]. Between 1945 and 2001, there were 90 imported cases of malaria and five malaria-related deaths reported by the Chilean Ministry of Health [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular and epidemiological characterization of imported malaria cases in Chile

Escobar

Lucchi

Abdallah

et al. 2020

Malar J

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Background: Chile is one of the South American countries certified as malaria-free since 1945. However, the recent increase of imported malaria cases and the presence of the vector Anopheles pseudopunctipennis in previously endemic areas in Chile require an active malaria surveillance programme. Methods: Specimens from 268 suspected malaria cases-all imported-collected between 2015 and 2018 at the Public Health Institute of Chile (ISP), were diagnosed by microscopy and positive cases were included for epidemiological analysis. A photo-induced electron transfer fluorogenic primer real-time PCR (PET-PCR) was used to confirm the presence of malaria parasites in available blood samples. Sanger sequencing of drug resistance molecular markers (pfk13, pfcrt and pfmdr1) and microsatellite (MS) analysis were performed in confirmed Plasmodium falciparum samples and results were related to origin of infection. Results: Out of the 268 suspected cases, 65 were Plasmodium spp. positive by microscopy. A total of 63% of the malaria patients were male and 37% were female; 43/65 of the patients acquired infections in South American endemic countries. Species confirmation of available blood samples by PET-PCR revealed that 15 samples were positive for P. falciparum, 27 for Plasmodium vivax and 4 were mixed infections. The P. falciparum samples sequenced contained four mutant pfcrt genotypes (CVMNT, CVMET, CVIET and SVMNT) and three mutant pfmdr1 genotypes (Y184F/ S1034C/N1042D/D1246Y, Y184F/N1042D/D1246Y and Y184F). MS analysis confirmed that all P. falciparum samples presented different haplotypes according to the suspected country of origin. Four patients with P. vivax infection returned to the health facilities due to relapses. Conclusion: The timely detection of polymorphisms associated with drug resistance will contribute to understanding if current drug policies in the country are appropriate for treatment of imported malaria cases and provide information about the most frequent resistant genotypes entering Chile.

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Section: Introductionmentioning

confidence: 99%

Molecular and epidemiological characterization of imported malaria cases in Chile

Escobar

Lucchi

Abdallah

et al. 2020

Malar J

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“…En Chile, en el área del control de las infecciones parasitarias humanas, se han conseguido logros destacados como impedir la transmisión autóctona de la malaria en la región del extremo norte del país y declarar interrumpida la transmisión del agente causal de la enfermedad de Chagas mediante el insecto domiciliario Triatoma infestans 9,10 . La transmisión de la enfermedad de Chagas mediante transfusiones sanguíneas se controla a través del descarte de sangre que presente anticuerpos anti T cruzi, determinadas mediante pruebas de tamiz o screening.…”

Section: N V E S T I G a C I ó Nunclassified

Aspectos parasitológicos y epidemiológicos de los donantes de sangre seropositivos para Trypanosoma cruzi,en un hospital universitario

Galaz

García²,

Mercado

et al. 2007

Rev. méd. Chile

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“…registrándose entre 1990 y 2001, 66 nuevos casos en los distintos Servicios del país y 5 fallecimientos 7 . Según el boletín de enfermedades de notificación obligatoria ministerial, en 2003 hubo 6 nuevos casos y en 2004 se presentaron 7 nuevos casos.…”

Section: N V E S T I G a C I ó Nunclassified

“…De la serie reportada por Schenone y cols. sólo 30% de los 66 pacientes eran de nacionalidad chilena, todos habían estado en zonas maláricas (principalmente en África y Sudamérica), hubo una mortalidad de 8,8% y no se identificaron los subtipos de Plasmodium 7 .…”

Section: E S T I G a C I ó Nunclassified

Malaria: revisión retrospectiva de 12 casos no autóctonos en Chile

Carmona

et al. 2006

Rev. méd. Chile

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Malaria is a protozoan infection caused by four Plasmodia species transmitted by female Anopheles mosquito. Nearly 40% of the world population is at risk of acquiring the disease because of increasing resistance to treatment, climate changes and travels to endemic zones. We report twelve patients with diagnosis of malaria, supported by the identification of parasites on blood smear. All cases had traveled to endemic zones (Peru, Ecuador, Central America, Africa), but only three used chemoprophylaxis. Seven cases were infected with Plasmodium vivax and five cases with P. falciparum. Three of latter required intensive care. All patients were treated with standard drugs according to the severity and Plasmodium specie, with excellent results and no mortality.

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Malaria en Chile: 1913 - 2001

Cited by 13 publications

References 0 publications

Molecular and epidemiological characterization of imported malaria cases in Chile

Molecular and epidemiological characterization of imported malaria cases in Chile

Aspectos parasitológicos y epidemiológicos de los donantes de sangre seropositivos para Trypanosoma cruzi,en un hospital universitario

Malaria: revisión retrospectiva de 12 casos no autóctonos en Chile

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