Malaria-Associated Cytokine Changes in the Placenta of Women With Pre-Term Deliveries in Yaounde, Cameroon

Suguitan, Amorsolo L.; Cadigan, Timothy J.; Nguyen, Thu Anh; Zhou, Ainong; Leke, Robert J. I.; Metenou, Simon; Thuita, Lucy; Megnekou, Rosette; Fogako, Josephine; Leke, Rose G. F.; Taylor, Diane Wallace

doi:10.4269/ajtmh.2003.69.574

Cited by 68 publications

(72 citation statements)

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“…This suggests that maternal or fetal cells in the placenta may be the primary source of IFN-␥ during PM. In a previous study in Cameroon, IFN-␥ was produced by fetal villi but not by maternal immune cells collected from infected placentas (37). The placenta secretes numerous cytokines and immunomodulatory molecules in addition to IFN-␥, and these molecules could play an important role in maternal and fetal outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…TNF-␣ and IL-10 are expressed by the maternal inflammatory cells that infiltrate the infected placenta, while IFN-␥ is secreted by placental villi, suggesting that the source is fetal (37). Elevated cord blood levels of ferritin, a marker of inflammation, were also recently found to increase the risk of LBW in a small study in Malawi (2).…”

mentioning

confidence: 97%

“…Placental levels of the inflammatory cytokine tumor necrosis factor alpha (TNF-␣) have also been related to LBW caused by PM (12,33,37), while the roles of gamma interferon (IFN-␥) and interleukin-10 (IL-10) have been controversial (12,33,37). TNF-␣ and IL-10 are expressed by the maternal inflammatory cells that infiltrate the infected placenta, while IFN-␥ is secreted by placental villi, suggesting that the source is fetal (37).…”

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confidence: 99%

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Fetal Responses during Placental Malaria Modify the Risk of Low Birth Weight

et al. 2008

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Inflammation during placental malaria (PM) is associated with low birth weight (LBW), especially during the first pregnancy, but the relative contribution of maternal or fetal factors that mediate this effect remains unclear and the role of gamma interferon (IFN-␥) has been controversial. We examined the relationship of maternal and cord plasma levels of IFN-␥, tumor necrosis factor alpha, interleukin-10, ferritin, and leptin to birth weight for Tanzanian women delivering in an area where there is a high rate of malaria transmission. The placental levels of inflammatory cytokines, including IFN-␥, increased significantly during PM in primigravid and multigravid women but not in secundigravid women. PM also increased maternal peripheral levels of all inflammatory markers except IFN-␥ but had strikingly little effect on cord levels of these proteins. In a multivariate analysis, placental IFN-␥ was negatively associated (P ‫؍‬ 0.01) and cord ferritin was positively associated (P < 0.0001) with birth weight in infected (PM-positive [PM ؉ ]) first-time mothers. This relationship was not observed in other mothers, consistent with the epidemiology of PM and disease. Cord leptin had a strong positive relationship with birth weight in offspring of PM-negative women (P ‫؍‬ 0.02 to P < 0.0001) but not in offspring of PM ؉ women (all differences were not significant) in the three gravidity groups. The results confirmed that placental IFN-␥ is related to LBW due to PM during first pregnancies and suggest that fetal ferritin plays a protective role. Because fetal cells are a source of placental IFN-␥ and cord ferritin, the fetal response to PM may modify the risk of LBW.

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Section: Discussionmentioning

confidence: 99%

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confidence: 97%

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confidence: 99%

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Fetal Responses during Placental Malaria Modify the Risk of Low Birth Weight

et al. 2008

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“…A bias toward a Th2 placental environment, e.g., IL-10, characterizes normal human pregnancy and is thought to prevent inflammatory responses that might damage the integrity of the materno-fetal placental barrier (24,25). During placental malaria, despite the placental shift toward Th1-type cytokines (8,26), IL-10 concentrations are elevated compared with healthy placentas (8). Active placental malaria at delivery further reduces parasite Ag-induced Th1 responsiveness in cord blood cells, as well as proliferative responses (27,28).…”

Section: P Lasmodium Falciparum (Pf)mentioning

confidence: 99%

IFN-γ and IL-10 Mediate Parasite-Specific Immune Responses of Cord Blood Cells Induced by Pregnancy-Associated Plasmodium falciparum Malaria

Brustoski

Möller

Kramer

et al. 2005

The Journal of Immunology

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Available evidence suggests that immune cells from neonates born to mothers with placental Plasmodium falciparum (Pf) infection are sensitized to parasite Ag in utero but have reduced ability to generate protective Th1 responses. In this study, we detected Pf Ag-specific IFN-γ+ T cells in cord blood from human neonates whose mothers had received treatment for malaria or who had active placental Pf infection at delivery, with responses being significantly reduced in the latter group. Active placental malaria at delivery was also associated with reduced expression of monocyte MHC class I and II in vivo and following short term in vitro coculture with Pf Ag compared with levels seen in neonates whose mothers had received treatment during pregnancy. Given that APC activation and Th1 responses are driven in part by IFN-γ and down-regulated by IL-10, we examined the role of these cytokines in modulating the Pf Ag-specific immune responses in cord blood samples. Exogenous recombinant human IFN-γ and neutralizing anti-human IL-10 enhanced T cell IFN-γ production, whereas recombinant human IFN-γ also restored MHC class I and II expression on monocytes from cord blood mononuclear cells cocultured with Pf Ag. Accordingly, active placental malaria at delivery was associated with increased frequencies of Pf Ag-specific IL-10+CD4+ T cells in cord blood mononuclear cell cultures from these neonates. Generation and maintenance of IL-10+ T cells in utero may thus contribute to suppression of APC function and Pf Ag-induced Th1 responses in newborns born to mothers with placental malaria at delivery, which may increase susceptibility to infection later in life.

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“…Penelitian yang dilakukan [40], yang menggunakan kultur su leukosit yang di ambil di ruang intervillous plasenta terinfeksi malaria menunjukkan bahwa sitokin IL-10 sekresinya lebih tinggi dari pada kultur yang menggunakan plasenta yang tidak terinfeksi malaria.. Produksi IL-10 meningkat karena efek imunoregulatornya yang menekan dominansi Th1 pada malaria plasenta. Tingginya IL-10 di malaria plasenta berasosiasi dengan terjadinya anemia pada ibu dan janin mengalami lahir prematur [40]. Tabel 2 menunjukkan fungsi kemokin dan sitokin selama malaria plasenta…”

Section: Repon Imun Terhadap Infeksi Malaria Selama Kehamilanunclassified

Malaria Pada Kehamilan Dan Konsekuensinya Pada Ibu Dan Janin

Rahmah

2017

JIM

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ABSTRAKMalaria merupakan penyakit infeksi yang masih menjadi masalah kesehatan utama di dunia. Malaria menyerang individu tampa membedakan umur dan jenis kelamin tidak terkecuali ibu hamil. Ibu hamil memiliki resiko terserang malaria oleh parasit Plasmodium lebih berat di bandingkan dengan wanita tidak hamil. Ketika seorang hamil akan terjadi supresi imun baik humoral maupun seluler Tujuan makalah ini untuk membahas mekanisme terjadinya malaria pada kehamilan dan konsekuensinya pada ibu dan janin. Adhesi parasit dengan reseptor Chondroitin Sulfate A (CSA) dan Hyaluronic Acid (HA) di plasenta dapat memicu proses inflamasi yang melibatkan sekresi sitokin. Komponen inflamasi yang muncul setelah akumulasi parasit di plasenta berasosiasi dengan patologi imun pada Pregnancy-Associated Malaria (PAM), seperti penebalan membran sitotrofoblas yang mengganggu aliran darah, menghambat transfer IgG melintasi plasenta dan pertukaran nutrisi dari ibu ke janin sehingga terjadi lesi pada plasenta. Selama kehamilan yang terinfeksi malaria terjadi proses cytoadherence di mediasi oleh protein Plasmodium falciparum Erythrocyte Membran Protein-1 (PfEMP-1) dikode oleh gen Var2 CSA yang mengikat reseptor di plasenta hal ini menyebabkan sekuestrasi eritrosit terinfeksi di sel endotel yang mengakibatkan terjadinya anemia pada ibu sedangkan pada janin menyebabkan berat badan lahir rendah, lahir prematur dan lahir mati. Kata kunci : Malaria, Ibu Hamil, Janin ABSTRACTMalaria is an infectious disease remains a major health problem in the world. Malaria attacks without differentiating individual age and sex of pregnant women are no exception. Pregnant women have a risk of malaria by Plasmodium parasites is more severe in comparison with non-pregnant women. When a pregnancy will occur immunosuppression both humoral and cellular purpose of this paper is to discuss the mechanism of occurrence of malaria in pregnancy and its consequences on the mother and fetus. Parasite adhesion receptors Chondroitin Sulfate A (CSA) and Hyaluronic Acid (HA) in the placenta can trigger an inflammatory process involving the secretion of cytokines. Inflammatory component that appears after the accumulation of parasites in the placenta is associated with immune pathology in the Pregnancy-Associated Malaria (PAM), such as thickening of the membrane cytotrophoblasts that disrupt blood flow, inhibiting the transfer of IgG across the placenta and the exchange of nutrients from mother to fetus, causing lesions in the placenta. Malaria infection during pregnancy is a process of mediation by protein cytoadherence in Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) encoded by genes that bind to receptors on Var2CSA this causes placental sequestration of infected erythrocytes on endothelial cells resulting in anemia in pregnant while on fetus causes low birth weight, premature birth and stillbirth.

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Malaria-Associated Cytokine Changes in the Placenta of Women With Pre-Term Deliveries in Yaounde, Cameroon

Cited by 68 publications

References 42 publications

Fetal Responses during Placental Malaria Modify the Risk of Low Birth Weight

Fetal Responses during Placental Malaria Modify the Risk of Low Birth Weight

IFN-γ and IL-10 Mediate Parasite-Specific Immune Responses of Cord Blood Cells Induced by Pregnancy-Associated Plasmodium falciparum Malaria

Malaria Pada Kehamilan Dan Konsekuensinya Pada Ibu Dan Janin

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