Malakoplakia of Bone

Choudhury, Monisha; Bajaj, Pramila; Jain, Renu; Nangia, Anita; Aneja, Sangeeta

doi:10.1159/000327638

Cited by 4 publications

(6 citation statements)

References 9 publications

(14 reference statements)

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“…This observation suggests that a foreign glycolipid material, possibly of E. coli origin, may play an etiologic role. Immunosuppression also appears to be associated with malakoplakia and was present in four of the nine cases involving bone 12,13,[15][16][17][18][19][20] .…”

Section: Discussionmentioning

confidence: 99%

“…The radiographic appearance is usually that of a permeative lesion and, often, a pathologic fracture 12,13,[15][16][17][18][19][20] . For the treating surgeon, the finding of edema on MRI can be suggestive of a pathologic process such as infection or neoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…In these instances, biopsy and culture may be needed. Treatment of malakoplakia of bone is favorable when surgery is paired with antibiotics that have good intracellular penetration 12,13,[15][16][17][18][19][20] . Although malakoplakia involving bone is rare, surgeons and pathologists should be aware that it can present as a mass-like lytic lesion.…”

Section: Discussionmentioning

confidence: 99%

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Malakoplakia of Bone

Lane

Land

Thompson

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Malakoplakia of Bone

Lane

Land

Thompson

et al. 2014

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“…There are fewer than 500 cases reported in medical literature with the majority of these presenting in the genitourinary tract. Lesions have also been reported affecting the skin, lungs, bone, thyroid and gastrointestinal systems 5 9–18. Almost all published cases of malakoplakia have been in patients who are immunosuppressed, although cases of malakoplakia in immunocompetent individuals have been reported 19 20…”

Section: Introductionmentioning

confidence: 99%

Cutaneous malakoplakia presenting as a groin swelling and graft failure

Macdonald¹,

Moyes

Clancy

et al. 2019

BMJ Case Rep

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Malakoplakia (from the Greek malakos, ‘soft’ and plakos ‘plaque’) is a granulomatous inflammatory condition, commonly presenting as a plaque in the genitourinary system, but has been shown to affect a wide variety of structures including the skin. Presentation is varied and a high degree of clinical suspicion is needed to make a diagnosis. We report a case of cutaneous malakoplakia presenting as an inguinal swelling in a 48-year-old kidney transplant patient with temporally associated graft dysfunction. New groin swelling in an immunosuppressed patient often prompts investigation centred on a malignant cause. While this is often appropriate, less common infectious and inflammatory causes should be considered. This case highlights the importance of thorough workup and investigation, including histopathology, in immunosuppressed cohorts and acts as a reminder that less common and more complex diagnoses warrant consideration in this group.

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“…Although these plaques can occur throughout the body, up to 58% of cases are localized to the genitourinary tract, with bone seldom affected 3,4 . To our knowledge, 10 cases of malakoplakia of bone have previously been reported, with only 2 cases involving the vertebra [5][6][7][8][9][10][11][12][13][14] .…”

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confidence: 99%

Surgically Managed Malakoplakia of the Spine

Petrusky²,

Babu³

et al. 2021

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Case: A 66-year-old woman with polymyositis and recurrent urinary tract infections presented with lumbar pain and progressive lower extremity neuropathy. Imaging showed lytic destruction of the vertebral bone from L2 to L4 with extension into adjacent musculature. Histological examination demonstrated Michaelis-Gutmann bodies consistent with malakoplakia. The patient underwent revision T12-sacrum posterior fusion, L2-5 laminectomy, and anterior L3-4 corpectomy, followed by L2-4 anterior stabilization and a 6-week course of ceftriaxone. At 3 months postoperatively, she was asymptomatic without recurrence. Conclusion: Malakoplakia of bone should be considered in the differential diagnosis of lytic bone lesions and can be effectively treated with surgical debulking with penetrative antibiotics.

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Malakoplakia of Bone

Cited by 4 publications

References 9 publications

Malakoplakia of Bone

Malakoplakia of Bone

Cutaneous malakoplakia presenting as a groin swelling and graft failure

Surgically Managed Malakoplakia of the Spine

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