Malakoplakia and Rosi Dorfman’s Disease co-existing in the same uterus , a very rare histopathological ldiagnoses mimicking malignancy

Abstract

Background Malakoplakia (MP) and Rosi Dorfman’s Disease (RDD) of the uterus are both parts of Xanthoganulomatouse disease spectrum ; a very rare inflammatory disease process characterized by histiocytic infiltration of the endometrium, and occasionally may be misdiagnosed as cancer. We believe that our case is the first reported case of the coexistence of both RDD and MP. Case presentation A 66-year-old woman presented with recurrent post-menopausal bleeding. .A pelvic ultrasound scan showed endometrial thickness of eight mm and no adnexal masses. An endometrial biopsy was suggestive of Xanthogranuloma endometritis (XE). Thereafter, total abdominal hysterectomy and bilateral salpingo-oophorectomywere performed,and the histopathology confirmed the co-existenceof both uterine malakoplakia (MP) and Rosi Dorfman’s disease (RDD). Conclusion MP and RDD are both rare inflammatory diseases may be misdiagnosed as malignancy. If treated inappropriately it may lead to systemic infection and recurrent infections . Histopathological diagnostic approach will definitely add to the clinical management of such cases .