2014
DOI: 10.1016/j.jpeds.2014.07.035
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Malakoplakia and Primary Immunodeficiency

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Cited by 7 publications
(13 citation statements)
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“…2 Malakoplakia typically affects adult patients, with an average age of 50 years at presentation. 3 Of the more than 500 described cases of malakoplakia, fewer than 15 have been reported in pediatric patients. 3 Our patient presented with E coli-associated skin and soft tissue infection, with clinical progression despite appropriate antimicrobial treatment, probably due to severe neutropenia.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…2 Malakoplakia typically affects adult patients, with an average age of 50 years at presentation. 3 Of the more than 500 described cases of malakoplakia, fewer than 15 have been reported in pediatric patients. 3 Our patient presented with E coli-associated skin and soft tissue infection, with clinical progression despite appropriate antimicrobial treatment, probably due to severe neutropenia.…”
Section: Discussionmentioning
confidence: 99%
“…3 Of the more than 500 described cases of malakoplakia, fewer than 15 have been reported in pediatric patients. 3 Our patient presented with E coli-associated skin and soft tissue infection, with clinical progression despite appropriate antimicrobial treatment, probably due to severe neutropenia. With additional immunosuppression to treat suspected ulcerative PG, histopathologic malakoplakia-like features developed.…”
Section: Discussionmentioning
confidence: 99%
“…The pathogenesis of malakoplakia is believed to result from incompletely destroyed bacteria by macrophages that exhibit defective phagolysosomal activity 21 . It has been reported to be associated with immune deficiency states, including lupus erythematosus, tuberculosis, sarcoidosis, diabetes mellitus, human immunodeficiency virus, and in several renal transplant recipients 4,19,22,23 . Of the reported cases, none have been identified in liver transplant patients.…”
Section: Discussionmentioning
confidence: 99%
“…21 It has been reported to be associated with immune deficiency states, including lupus erythematosus, F I G U R E 1 Abdominal MRI demonstrating an 8.2 × 7.2 × 7.1 cm 3 aggressive appearing mass arising from the superior pole of the right kidney with extension into the medullary space and right hemidiaphragm tuberculosis, sarcoidosis, diabetes mellitus, human immunodeficiency virus, and in several renal transplant recipients. 4,19,22,23 Of the reported cases, none have been identified in liver transplant patients.…”
Section: Case Description and Pathology Findingsmentioning
confidence: 99%
“…The most common site of involvement is the genitourinary (GU) tract, but lesions have been documented in the gastrointestinal (GI) tract, lungs, skin, bone, conjunctiva, adrenal gland, and very rarely in the liver 7 . Of approximately 40 cases of cutaneous malakoplakia documented in the literature, just 4 affected pediatric patients 1,5,8–10 . Only 7 cases of hepatic malakoplakia in adults have been reported 3 .…”
Section: Introductionmentioning
confidence: 99%