Malakoplakia and colonic adenoma: A rare association

Colonic Adenocarcinoma With Malakoplakia of Colon - A Case Report

“…[9] and occurs in conjunction with tumors and non-tumoral conditions. [10,11] Most of these had a coexistent colonic adenocarcinoma, similarly to our case.…”

Malakoplakia in a colonic tubular adenoma: a unique case presentation

“…The mode of the occurrence in relation to age is characterised by bimodal pattern, the first prevalence is below age of 13 and the second group is the middle -aged adults, however the average age at diagnosis is 50 years [12][13][14][15][16][17][18]. It has since been reported at other sites, including the gastrointestinal tract (GIT) [7,8,19], the skin [9], the vagina [10], the central nervous system [20], the lungs [21], pancreas [15] and the gallbladder [22].The second group is the middle-aged adults, however the average age at diagnosis is 50 years [12][13][14]. Clinical presentation varies from incidental finding during a procedure, to a symptomatic mass lesion.…”

“…The histiocytes have enlarged phagosomes containing non-digested bacteria along with cytoplasmic mineralized basophilic concretions with a targetoid appearance, surrounded by a simple lysosomic-type membrane and there are termed Michaelis-Gutmann bodies (MGBs) [4,5]. This reaction is most commonly seen in the urinary bladder [6], but has also been reported in the gastrointestinal system [7,8], skin [9] and vagina [10]. Incidental findings of malakoplakia in the gastrointestinal tract have been shown to have an association with colorectal carcinoma [11].…”

Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

“…Three possible pathogenetic mechanisms have been suggested: an unusual causative organism, an abnormal or altered immune response and an abnormal macrophage response due to defective lysosomal function [12] . Colonic malakoplakia was first described by Terner and Lattes in 1965 [13] and has been reported to occur in conjunction with tumors and non-tumoral conditions [14][15][16] . Since 1965 about 95 cases of colonic malakoplakia have been published.…”