Maladies immunologiques et virus de l'hépatite C

Malaguarnera, Mariano; Restuccia, N.; Laurino, A; Giugno, I; Ba, Trovato; Motta, Massimo

doi:10.1016/0248-8663(96)81434-2

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…However, other studies revealed a greater correlation between the response to IFN and viremia levels despite various genotypes e~amined.~' It must be kept in mind that hepatitis C infection is sometimes associated with many systemic complications,68 such as forms of autoimmune hepatitis, cryoglobulinemia, porphyria cutanea tarda, lymphocytic sialoadenitis, and membranous glomerulonephritis, that can be treated with immunosuppressors and cortisone, even if they significantly augment hepatitis C virus RNA levels. 69 To date the sole treatment for chronic hepatitis D is prolonged administration of highdose IFN, but unfortunately the prognosis is poor.…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

Interferon, Cortisone, and Antivirals in the Treatment of Chronic Viral Hepatitis: A Review of 30 Years of Therapy

Malaguarnera,

Restuccia,

Motta

et al. 1997

Pharmacotherapy

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Over the last 30 years many approaches have been adopted to treat chronic hepatitis. We conducted a meta‐analysis to assess the efficacy of various types of treatments. We selected 4 studies of cortisone in chronic hepatitis B; 21 trials of interferon treatment, 6 in chronic hepatitis B, 10 in chronic hepatitis C, and 5 in chronic hepatitis D; and 5 of combined cortisone and interferon treatment in chronic hepatitis B. The Mantel‐Haenszel‐Peto method was applied to extrapolated data. We completed the study by analyzing four studies of cortisone treatment of chronic hepatitis C, two of cortisone plus interferon a (IFN‐α) for chronic hepatitis C, and antiviral therapy for hepatitis B, C, and D. Trials administering cortisone for chronic hepatitis B had an overall OR of 0.29 (CI 0.12‐0.73). No virologic remissions were observed in patients with hepatitis C receiving prednisone, even if those with features of autoimmunity achieved a biohumoral sustained response. Overall ORs in the trials were were as follows: IFN for chronic hepatitis B, 0.27 (CI 0.17‐0.46); IFN for chronic hepatitis C, 0.3 (CI 0.21‐0.44); IFN for chronic hepatitis D, 0.16 (CI 0.06‐0.47); and cortisone plus interferon for chronic hepatitis B, 0.25 (CI 0.15‐0.41). Sustained response rates of chronic hepatitis C ranged from 15–24.2%. The only encouraging results were obtained by antivirals. To date the lack of a specific antiviral drug makes it uncertain as to the preferred agent for this disease.

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Section: Therapeutic Strategiesmentioning

confidence: 99%

Interferon, Cortisone, and Antivirals in the Treatment of Chronic Viral Hepatitis: A Review of 30 Years of Therapy

Malaguarnera,

Restuccia,

Motta

et al. 1997

Pharmacotherapy

View full text Add to dashboard Cite

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Colonic Ulcers in a Patient With Hepatitis C Virus-Associated Polyarteritis Nodosa

Elias

Sabo

Naschitz

et al. 1998

Journal of Clinical Gastroenterology

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An elderly woman presented with abdominal discomfort, pulmonary infiltrates, acute renal failure, purpura, and massive hematochezia. Numerous colonic ulcers with underlying fibrinoid necrotizing arteritis were found in the colectomy specimen. Anti-hepatitis C virus (HCV) antibodies and HCV RNA were present in the serum. The diagnosis of HCV-associated polyarteritis nodosa was clear. This clinical presentation differs from the more commonly occurring vasculitis complicating HCV infection, which is of the leukocytoclastic type, and is associated with overt liver disease and cryoglobulinemia. In our patient, results of liver tests were normal, there was no cryoglobulinemia, and the vasculitis was of the fibrinoid necrotizing arteritis type. HCV-associated polyarteritis nodosa should be considered in the differential diagnosis of necrotizing fibrinoid arteritis even in a patient with normal liver function test results and in the absence of cryoglobulinemia.

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Increased Colonic Intraepithelial Lymphocytes in Patients With Hashimoto's Thyroiditis

Cındoruk

Tuncer

Dursun

et al. 2002

Journal of Clinical Gastroenterology

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Maladies immunologiques et virus de l'hépatite C

Cited by 5 publications

References 40 publications

Interferon, Cortisone, and Antivirals in the Treatment of Chronic Viral Hepatitis: A Review of 30 Years of Therapy

Interferon, Cortisone, and Antivirals in the Treatment of Chronic Viral Hepatitis: A Review of 30 Years of Therapy

Colonic Ulcers in a Patient With Hepatitis C Virus-Associated Polyarteritis Nodosa

Increased Colonic Intraepithelial Lymphocytes in Patients With Hashimoto's Thyroiditis

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