Maladie de Kimura de la glande lacrymale : à propos d’un cas

Audelan, T; Jamart, Céline; Héron, Emmanuel; Keilani, Chafik; Meney, J.; Sahel, José‐Alain; Pâques, M.; Boumendil, J.

doi:10.1016/j.jfo.2020.10.009

Cited by 1 publication

(4 citation statements)

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“…Surgery may be considered first, especially for localized lesions, even if recurrence is possible (42%-66%), and is the most commonly used treatment, helping to achieve a definitive diagnosis, although recurrence is common [12]. In patients with a maximum tumor diameter of <3 cm, surgery is an effective single treatment [16].…”

Section: Discussionmentioning

confidence: 99%

“…It has not been the most widely used option due to its cosmetic outcome and toxicities, including the risk of second malignancies [3]. The observed recurrence rate is 30% to 50% [12]. A recent study showed that radiotherapy (20-45 Gy) was more effective than local excision and steroid treatment, with a local response rate of 64.3% (versus 22.2% in the steroid group) [7].…”

Section: Discussionmentioning

confidence: 99%

“…Despite being a benign disease, the recurrence of KD is very common (up to 60%-80%) [13]. The course of the disease is chronic, with periods of remission or even spontaneous regression and recurrence [12]. The overall outcome is good as it is not associated with malignancy [17].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment of the disease depends on the clinical presentation and is not uniform. Surgical excision is often the first-line treatment, especially for small and accessible lesions, with a 100% success rate but a 42%-66% recurrence rate [12]. Complete surgical clearance is challenging due to the infiltrative nature of the disease and regional lymphadenopathy [3].…”

Section: Introductionmentioning

confidence: 99%

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Kimura's Disease: A Literature Review Based on a Clinical Case

Brito,

Baptista,

Pereira

et al. 2023

Cureus

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Kimura's disease (KD) was first described in 1937. It is a rare, benign, and chronic immune-mediated inflammatory disorder affecting the subcutaneous tissue, salivary glands, and lymph nodes. The disease is more common in the second to third decades of life in middle-aged Southeast Asian countries. The cause of Kimura's disease remains unknown; some authors believe it is related to an autoimmune or delayed-type hypersensitivity reaction. It commonly presents as a solitary painless lymph node in the head and neck or generalized lymphadenopathy (67%-100%) associated with peripheral eosinophilia and elevated IgE levels. Renal involvement may occur in some patients. Diagnosis is made by histology.A 21-year-old Caucasian man with no relevant medical history presented with a non-tender swelling of the left hemiface without other associated symptoms. Laboratory investigations revealed a leukocyte count with eosinophilia (2.29×10^9/L-26.5%) and elevated total IgE and IgG4. He had no renal dysfunction. He underwent surgical resection of the lesion in the jugal, infraorbital, and left nasolabial regions, and the anatomopathological examination revealed the characteristics of Kimura's disease. Three months after surgery, an MRI showed an increase in the size of the mass, and he was started on corticosteroids. Six months after surgery, he presented with a slight increase in the size of the mass and was started on Ciclosporin, which allowed a progressive reduction in the dose of corticosteroid with evidence of a progressive reduction in swelling. Ciclosporin was stopped due to toxic serum levels, and he was started on mycophenolate mofetil. The dose was increased because of the increase in facial mass; on mycophenolate mofetil 2500mg/day, the patient remains stable.KD is a chronic disorder of unknown etiology that mainly affects young people in Southeast Asia and is rare in Western countries, as in the case of this young man. Studies have shown no significant differences in region or race, complications, multiplicity, laterality, anatomical distribution, maximum size, eosinophil count, or IgE levels between age groups. There is no consensus on the optimal treatment for KD; several treatments have been used, including surgery, systemic corticosteroids, immunosuppressants, and radiation. Due to the tendency to relapse and the rarity of the disease, there is no consensus on treatment options for relapse.

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Section: Discussionmentioning

confidence: 99%