Maladie de Hodgkin de l’enfant. Expérience marocaine

Harif, Mhamed; Madani, Abdellah; Hessissen, Laïla; Zafad, S.; Khattab, Mohamed; Quessar, Asmaa; Benchekroun, Saïd

doi:10.1016/s0929-693x(09)74108-9

Cited by 4 publications

(9 citation statements)

References 5 publications

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“…In studies from Morocco and India, the age group 6 -14 years was the most affected. [18,19] The early onset of HL in children in LMICs is thought to be due to early infection with EBV, although the role of the virus in the pathogenesis of HL remains partly enigmatic. [20,21] EBV was found in 68% and 93% of paediatric HL cases in South Africa and Malaysia, respectively.…”

Section: Discussionmentioning

confidence: 99%

Treatment of childhood Hodgkin lymphoma in sub-Saharan Africa: A report from the French-African Paediatric Oncology Group (GFAOP)

Akondé

Togo²,

Moreira

et al. 2020

S Afr J CH

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This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0. Hodgkin lymphoma (HL) is a B-cell line lymphoma, characterised histologically by the presence of large, atypical cells called Reed-Sternberg cells. The first histological description dates back to 1832 by Thomas Hodgkin. [1] Epstein-Barr virus (EBV) is an important factor in the pathogenesis of HL and it is detected in Reed-Sternberg cells in the vast majority of HL specimens from developing countries, but much less frequently in high-income countries. [2] The incidence of HL is 1.2 per 100 000 children and represents the most common malignant tumour in adolescents in high-income countries, and the majority of cases are diagnosed at an early stage of disease. [3] Hodgkin's disease is more common in children under 10 years of age in developing countries. HL is a malignant but highly curable tumour and its treatment is one of the success stories of modern medicine. The use of chemotherapy combined with radiotherapy has greatly improved the survival rate of advanced stages of the disease. In high-income countries, the event-free survival and overall survival rates are 85% and 90%, respectively. [4,5] The reported results of therapy of HL in low-and middle-income countries (LMICs) are not as good, due to several factors. [6,7] One of the key reasons is that radiation therapy centres in sub-Saharan Africa are rare, but efforts are underway to address this issue. [8,9] Studies from one institution using chemotherapy alone in the treatment of HL have shown encouraging results. [10,11] This therapeutic strategy has been adopted by the French-African Paediatric Oncology Group (GFAOP) to improve the treatment of children with HL in sub-Saharan Africa. In this article, we present the results of a prospective, collaborative, multicentre study on the management of HL using only chemotherapy in GFAOP institutions. Methods This was a prospective, multicentre study aimed at evaluating the feasibility of using only COPP/ABV hybrid chemotherapy (cyclophosphamide, vincristine, procarbazine, prednisone, adriamycin, bleomycin and vinblastine) in treating children diagnosed Background. Childhood Hodgkin lymphoma (HL) is typically treated by chemo-and radiotherapy, depending on the stage of the disease. Studies on the treatment of HL by chemotherapy alone have shown encouraging results. Objective. To evaluate the feasibility, epidemiological and therapeutic aspects of paediatric HL treated with only COPP/ABV hybrid chemotherapy (cyclophosphamide, vincristine, procarbazine, prednisone, adriamycin, bleomycin and vinblastine). Methods. This was a prospective multicentre study on the management of HL in paediatric oncology centres of the French-African Paediatric Oncology Group in sub-Saharan Africa, from 1 October 2006 to 30 November 2012. To be included in the study, patients had to be younger than 18 years at diagnosis, with histologically proven HL. Results. A total of 106 patients were included, with a median age of 10 years (range: 2-18 years). The s...

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Section: Discussionmentioning

confidence: 99%

Treatment of childhood Hodgkin lymphoma in sub-Saharan Africa: A report from the French-African Paediatric Oncology Group (GFAOP)

Akondé

Togo²,

Moreira

et al. 2020

S Afr J CH

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“…The diagnosis can also be evoked before general signs such as fever, night sweats, and general fatigue with weight loss. These signs testify to the progression of the disease and lead to a radiological assessment which will guide the diagnosis [6]. Our patient initially presented a painless cervical swelling gradually increasing in size with the onset of fever.…”

Section: Discussionmentioning

confidence: 86%

“…In the series of Amégbor K et al [4] in Togo, the mean age of the patients was 9.7 years, with a peak in frequency between 10 and 14 years. In the study of Harif M et al [6] in Morocco, the mean age is 10.3 years, of which 15% of patients are 5 years old or less. This is also the case with our patient because the disease appeared at the age of 5 years.…”

Section: Discussionmentioning

confidence: 97%

“…However, the different epidemiological studies supporting the existence of multiple risk factors require a profound methodological validation of their result [5]. HL is a pathology predominant in boys (sex ratio: 3 to 4) [4,6]. In developed countries, it is a condition of young adults and the elderly.…”

Section: Discussionmentioning

confidence: 99%

“…This is also the case with our patient because the disease appeared at the age of 5 years. Clinically, according to Harif M et al [6], HL is mainly lymph node localization. Lymphadenopathy, in particular cervical lymphadenopathy, is the usual way of revealing the disease.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Fine Needle Aspiration Cytology in Diagnosis of Hogdkin Lymphoma: A Case Report and Review of Literature

Ranaivomanana

Raivoherivony

Andrianarison

et al. 2022

IJRBP

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Hodgkin disease is a malignant pathology of lymphatic system. It’s rare in children and less common than non Hodgkin lymphoma. We report a case of Hodgkin lymphoma which has highlighted the value of cytological and histological examination in diagnosis. It was a 7 years-old boy with a painless cervical mass that had progressed for 2 years without treatment and increased in volume. The cervical ultrasound suspected a benign cystic mass, while the CT scan showed a tissue nodule, highly vascularized. Fine needle aspiration of this nodule was made. The cytological examination showed an inflammatory granuloma with rare atypical, binucleated cells suspect of Hodgkin lymphoma which was confirmed by histology. In developing countries, cytology is an easier and cheaper test to perform with a quick result which helps to orient the diagnosis towards Hodgkin lymphoma? However, it is necessary to make a histological diagnostic confirmation.

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Hodgkin Lymphoma

Stefan¹,

Harif²

2017

Pediatric Cancer in Africa

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Maladie de Hodgkin de l’enfant. Expérience marocaine

Cited by 4 publications

References 5 publications

Treatment of childhood Hodgkin lymphoma in sub-Saharan Africa: A report from the French-African Paediatric Oncology Group (GFAOP)

Treatment of childhood Hodgkin lymphoma in sub-Saharan Africa: A report from the French-African Paediatric Oncology Group (GFAOP)

Fine Needle Aspiration Cytology in Diagnosis of Hogdkin Lymphoma: A Case Report and Review of Literature

Hodgkin Lymphoma

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