Maladaptive Avoidance Learning in the Orbitofrontal Cortex in Adolescents With Major Depression

Willinger, David; Karipidis, Iliana I.; Neuer, S.; Emery, Sophie; Rauch, C.; Häberling, Isabelle; Berger, Gregor; Walitza, Susanne; Brem, Silvia

doi:10.1016/j.bpsc.2021.06.005

Cited by 5 publications

(8 citation statements)

References 50 publications

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“…As suggested by previous studies (Putkinen et al, 2021; Willinger et al, 2021), a full connectivity model (‘full’ model) was specified for each subject for DCM analysis, which included three sets of parameters: effective intrinsic connections between the three regions and their self-connections (matrix A); modulatory effects of SON on all connections between regions and self-connections (matrix B); and driving inputs (using all four auditory stimuli: SON, FN, UN, SONREV) into the left primary auditory cortex (matrix C) (Zeidman et al, 2019a). Specifically, the self-connection of Matrices A and B reflected the self-inhibition in each region, i.e., their gain or sensitivity to driving inputs (Zeidman et al, 2019a).…”

Section: Methodssupporting

confidence: 76%

Decoding Subject’s Own Name in the Primary Auditory Cortex

Wang

Liu

et al. 2022

Preprint

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Current studies have shown that perception of one's own name involves multiple multimodal brain regions, while activities in unimodal sensory regions (i.e., primary auditory cortex) and their interaction with multimodal regions during self-processing remain unclear. To answer this, we combined multivariate pattern analysis and dynamic causal modelling analysis to explore the regional activation pattern and inter-region effective connection during self-name processing. We found that subject's own name and other names could be decoded from the activation pattern in the primary auditory cortex. In addition, we found an excitatory effect of SON on connections from the anterior insula/inferior frontal gyrus to the primary auditory cortex, and to the temporal parietal junction. Our findings extended the current knowledge of self-processing by showing that primary sensory cortex could discriminate one's own name from other names. Furthermore, our findings highlighted the importance of influence of the insula on the primary auditory cortex during self-processing.

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Section: Methodssupporting

confidence: 76%

Decoding Subject’s Own Name in the Primary Auditory Cortex

Wang

Liu

et al. 2022

Preprint

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“…As suggested by previous studies (Putkinen et al, 2021 ; Willinger et al, 2021 ), a full connectivity model ('full' model) was specified for each subject for DCM analysis, which included three sets of parameters: effective intrinsic connections between the three regions and their self‐connections (matrix A); modulatory effects of SON on all connections between regions and self‐connections (matrix B); and driving inputs (using all four auditory stimuli: SON, FN, UN, SONREV) into the left primary auditory cortex (matrix C) (Zeidman, Jafarian, Corbin, et al, 2019 ). Specifically, the self‐connection of Matrices A and B reflected the self‐inhibition in each region, that is, their gain or sensitivity to driving inputs (Zeidman, Jafarian, Corbin, et al, 2019 ).…”

Section: Methodssupporting

confidence: 65%

Decoding subject's own name in the primary auditory cortex

Wang

Liu

et al. 2022

Human Brain Mapping

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Current studies have shown that perception of subject's own name (SON) involves multiple multimodal brain regions, while activities in unimodal sensory regions (i.e., primary auditory cortex) and their interaction with multimodal regions during the self‐processing remain unclear. To answer this, we combined multivariate pattern analysis and dynamic causal modelling analysis to explore the regional activation pattern and inter‐region effective connection during the perception of SON. We found that SON and other names could be decoded from the activation pattern in the primary auditory cortex. In addition, we found an excitatory effect of SON on connections from the anterior insula/inferior frontal gyrus to the primary auditory cortex, and to the temporoparietal junction. Our findings extended the current knowledge of self‐processing by showing that primary auditory cortex could discriminate SON from other names. Furthermore, our findings highlighted the importance of influence of the insula on the primary auditory cortex during self‐processing.

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“…However, those with a diagnosis of MDD recorded either no or attenuated change in Hb activation following exposure to the same negative stimuli (95, 96). Similarly, in an error prediction learning task, adolescents with MDD exhibited a reduction in negative related signalling in the Hb when compared to controls (98). Moreover, the reduction in loss-related prediction error correlated with anhedonia symptom severity 98).…”

Section: Resultsmentioning

confidence: 99%

The disappointment centre of the brain gets exciting: A systematic review of habenula dysfunction in depression

Cameron,

Weston-Green,

Newell

2024

Preprint

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Background: The habenula is an epithalamic brain structure that acts as a neuroanatomical hub connecting the limbic forebrain to the major monoamine centres. Abnormal habenula activity is increasingly implicated in depression, with a surge in publications on this topic in the last 5 years. Direct stimulation of the habenula is sufficient to induce a depressive phenotype in rodents, suggesting a causative role in depression. However, the molecular basis of habenula dysfunction in depression remains elusive and it is unclear how the preclinical advancements translate to the clinical field. Methods: A systematic literature search was conducted following the PRISMA guidelines. The two search terms depress* and habenula* were applied across the databases Scopus, Web of Science and PubMed. Studies eligible for inclusion must have examined changes in the habenula in clinical cases of depression or preclinical models of depression. Results: Preclinical studies (n=57) measured markers of habenula activity (n=16) and neuronal firing (n=21), largely implicating habenula hyperactivity in depression. Neurotransmission was briefly explored (n=13), suggesting imbalances within excitatory and inhibitory habenula signalling. Additional preclinical studies reported neuroconnectivity (n=1), inflammatory (n=2), genomic (n=2) and circadian rhythm (n=2) abnormalities. Seven preclinical studies (12.2%) included both males and females. From these, 5 studies (71%) reported a significant difference between the sexes in at least one habenula measure taken. Clinical studies (n=18) reported abnormalities in habenula connectivity (n=11), volume (n=5) and molecular markers (n=2). Clinical studies generally included male and female subjects (n=15), however, few of these studies examined sex as a biological variable (n=5) Conclusions: Both preclinical and clinical evidence suggest the habenula is disrupted in depression. However, there are opportunities for sex-specific analyses across both areas. Preclinical evidence consistently suggests habenula hyperactivity as a primary driver for the development of depressive symptoms. Clinical studies support gross habenula abnormalities such as altered activation, connectivity, and volume, with emerging evidence of blood brain barrier dysfunction, however, progress is limited by a lack of detailed molecular analyses.

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Maladaptive Avoidance Learning in the Orbitofrontal Cortex in Adolescents With Major Depression

Cited by 5 publications

References 50 publications

Decoding Subject’s Own Name in the Primary Auditory Cortex

Decoding Subject’s Own Name in the Primary Auditory Cortex

Decoding subject's own name in the primary auditory cortex

The disappointment centre of the brain gets exciting: A systematic review of habenula dysfunction in depression

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