Malabsorption Syndrome Associated with Intestinal Diverticulosis

The clinical and metabolic significance of jejunal diverticula

“…However, jejunal biopsy in eight patients who had severe absorptive defects showed little evidence of abnormality, cellular infiltration or oedema being seen in only three patients. Schiffer, Faloon, Chodos, and Lozner (1962) reported changes in the jejunal biopsy of a patient with jejunal diverticulosis, macrocytic anaemia, and steatorrhoea. They considered the findings similar to those found in coeliac disease, non-tropical sprue and tropical sprue, and the neomycin malabsorptive states.…”

“…Three patients were re-tested after a course of antibiotics and showed normal excretion of d-xylose. Low excretion values of d-xylose have been reported by Watkinson, Feather, Marson, and Dossett (1959), by Johnson and Wysor (1961), and by Schiffer, Faloon, Chodos, and Lozner (1962).…”

“…Megaloblastic anaemia and steatorrhoea were found in a woman of 25 by Wilkinson (1955). Kozinn and Jennings (1941) Blachford and Dawson (1956) Gellman (1956) Welbourn, Nelson, and Zacharias (1956) Halsted, Gasster, and Lewis (1956) Krevans, Conley, and Sachs (1956) Townsend and Cameron (1957) Scudamore, Hagedorn, Wollaeger, and Owen (1958) Lee and Finby (1958) Watkinson, Feather, Marson, and Dossett (1959) Doig and Girdwood (1960) Johnson and Wysor (1961) Crawford and Freeman (1961) Polachek, Pijanowski, and Miller (1961) Schiffer, Faloon, Chodos, and Lozner (1962) bacterial endocarditis. Investigations revealed jejunal diverticulosis, steatorrhoea, and intestinal infection as the cause of her symptoms.…”

Steatorrhoea in rats with an intestinal cul-de-sac

“…This correlates with studies in normal rats, where the jejunum is the normal site of fat absorption (Booth, Read, and Jones, 1961). In clinical cases of blind loop syndrome, too, steatorrhoea occurs preferentially when the anatomical defect is in the proximal part of the small intestine (Schiffer, Faloon, Chodos, and Lozner, 1962).…”

Jejunal Diverticulosis, Megaloblastic Anaemia and Partial Gastric Atrophy

“…Of these, eleven had achlorhydria, or nearly complete achlorhydria, and in two cases no comment had been made of gastric acidity. Schiffer, Faloon, Chodos and Lozner (1962) reported a case with jejunal biopsy findings. Cooke, Cox, Fone, Meynell and Caddie (1963) again reviewed the literature, and in an excellent study reported on the clinical and metabolic effects in thirty-three cases of jejunal diverticulosis.…”