Mal-effects of obstructive sleep apnea on the heart

Yang, Shu; Han, Li-li; Dong, Xiaolu; Wang, Chunyong; Xia, Huan; Liu, Pan; Wang, Jinghua; He, Pingping; Liu, Shengnan; Li, Mingxian

doi:10.1007/s11325-011-0566-1

Cited by 24 publications

(22 citation statements)

References 19 publications

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“…In patients with OSA the main mechanisms for development of PH are repetitive nocturnal hypoxemia, increased sympathetic tone, and wide swings in intrathoracic pressure [55, 56]. Cyclical intermittent hypoxemia can cause overexpression of ET-1 in pulmonary arteries [57].…”

Section: Pathophysiology Of Ph In Cldmentioning

confidence: 99%

Pulmonary Hypertension and Right Heart Dysfunction in Chronic Lung Disease

Zangiabadi

Pasquale

Sajkov

2014

BioMed Research International

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Group 3 pulmonary hypertension (PH) is a common complication of chronic lung disease (CLD), including chronic obstructive pulmonary disease (COPD), interstitial lung disease, and sleep-disordered breathing. Development of PH is associated with poor prognosis and may progress to right heart failure, however, in the majority of the patients with CLD, PH is mild to moderate and only a small number of patients develop severe PH. The pathophysiology of PH in CLD is multifactorial and includes hypoxic pulmonary vasoconstriction, pulmonary vascular remodeling, small vessel destruction, and fibrosis. The effects of PH on the right ventricle (RV) range between early RV remodeling, hypertrophy, dilatation, and eventual failure with associated increased mortality. The golden standard for diagnosis of PH is right heart catheterization, however, evidence of PH can be appreciated on clinical examination, serology, radiological imaging, and Doppler echocardiography. Treatment of PH in CLD focuses on management of the underlying lung disorder and hypoxia. There is, however, limited evidence to suggest that PH-specific vasodilators such as phosphodiesterase-type 5 inhibitors, endothelin receptor antagonists, and prostanoids may have a role in the treatment of patients with CLD and moderate-to-severe PH.

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Section: Pathophysiology Of Ph In Cldmentioning

confidence: 99%

Pulmonary Hypertension and Right Heart Dysfunction in Chronic Lung Disease

Zangiabadi

Pasquale

Sajkov

2014

BioMed Research International

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“…Moreover , OSAS also may lead to impairment of right ventricular functions regardless of the existence of pulmonary artery hypertension . Once right ventricle dysfunction develops in OSAS, disease deteriorates progressively in a rapid manner . Therefore, early recognition of right ventricle dysfunction in OSAS is a significant part of the diagnosis and treatment of the syndrome.…”

mentioning

confidence: 99%

Evaluation of Pulmonary Artery Stiffness in Patients with Obstructive Sleep Apnea Syndrome

Altıparmak

Erkuş

Polat³

et al. 2015

Echocardiography

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“…To summarize, LV diastolic dysfunction is often observed in OSAS patients, even in the early stage of the disease [75,76,79,84], and regardless of the severity. However, in mild-to-moderate OSAS, LV dysfunction seems to be linked primarily to extrarespiratory determining factors (age, BMI, AHT, LVH).…”

Section: Diastolic Dysfunction In Osasmentioning

confidence: 97%

“…Furthermore, several studies have shown various impaired LV diastolic function markers in patients with OSAS compared with in controls: enlarged left atrial size [46,[78][79][80], prolonged isovolumic relaxation time (IVRT) [46,57,78,81], altered E/A ratio [46,78,79,[81][82][83][84], lower early diastolic mitral annular velocity (e ) [79,82,83,85,86] and increased E/e ratio [43,78,87] (Fig. 3).…”

Section: Diastolic Dysfunction In Osasmentioning

confidence: 99%

Consequences of obstructive sleep apnoea syndrome on left ventricular geometry and diastolic function

Bodez

Damy

Soulat-Dufour³

et al. 2016

Archives of Cardiovascular Diseases

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Obstructive sleep apnoea syndrome (OSAS) is a frequent sleep disorder that is known to be an independent risk factor for arterial hypertension (AHT). Potential confounding factors associated with both OSAS and AHT, such as age, diabetes mellitus and obesity, have been explored extensively, and are considered as independent but additive factors. However, these factors are also contributors to left ventricular (LV) hypertrophy (LVH) and LV diastolic dysfunction, both of which are important causes of cardiovascular morbidity, and have been reported to be associated with OSAS for decades. In this review, we present an overview of how OSAS may promote changes in LV geometry and diastolic dysfunction through its best-known cardiovascular complication, arterial hypertension. We also summarize the epidemiological links between OSAS and LVH, outline diastolic dysfunction in OSAS patients, and try to highlight the mechanisms responsible, focusing on the effect of confounding factors.

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Mal-effects of obstructive sleep apnea on the heart

Abstract: OSA affected the left ventricular diastolic function in the early stage of the disease. Extended exposure to OSA resulted in left ventricular dysfunction with increased hypertension. Right ventricle dysfunction and abnormalities became more severe as the disease progressed.

Cited by 24 publications

References 19 publications

Pulmonary Hypertension and Right Heart Dysfunction in Chronic Lung Disease

Pulmonary Hypertension and Right Heart Dysfunction in Chronic Lung Disease

Evaluation of Pulmonary Artery Stiffness in Patients with Obstructive Sleep Apnea Syndrome

Consequences of obstructive sleep apnoea syndrome on left ventricular geometry and diastolic function

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