Makrophagen: Herkunft, Entwicklung und Funktion

Roos, B.

doi:10.1007/978-3-642-65044-4_1

Cited by 12 publications

(6 citation statements)

References 502 publications

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“…2 and 3&plus other lysosomes and many pseudopodia, showed their true nature. Such transformations have previously been reported in vivo (Roos, 1970;Vernon-Roberts, 1972;Carr, 1973) and in vitro (Casley-Smith and Day, 1965). A very important finding was the presence of many fibroblasts-and very greatly increased amounts of collagen fibres in the animals injected with plasma At still higher magnifications ( x 150,000) the characteristic micelles can organelles more clearly.…”

Section: Microscopy-qualitativesupporting

confidence: 67%

Excess plasma proteins as a cause of chronic inflammation and lymphoedema: Quantitative electron microscopy

Casley‐Smith

Gaffney

1981

The Journal of Pathology

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The subcutaneous tissue of rats was injected with plasma. PVP, or saline. In spite of precautions to avoid immunological reactions and the release of mediators, it was found that the plasma-injected animals had many of the signs of chronic inflammation-even at 64 days. These were considerably reduced by coumarin, a benzo-pyrone, which is known to enhance the lysis of proteins by macrophages. The numbers of these cells were greatly increased in the injection site-especially with the administration of coumarin. PVP also moderately increased macrophage numbers, but did not cause the increase in fibroblast numbers or collagen formation associated with plasma-injections. It is concluded that altered proteins in the tissues are a cause of chronic inflammation and that, in particular, chronic lymphoedema is a form of chronic inflammation.

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Section: Microscopy-qualitativesupporting

confidence: 67%

Excess plasma proteins as a cause of chronic inflammation and lymphoedema: Quantitative electron microscopy

Casley‐Smith

Gaffney

1981

The Journal of Pathology

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“…These increase liver and spleen weights (ROOS, 1970). Others act by increasing the probability of particle engulfment (HOEBEKE & FRANCHI, 1973), and have no effect on liver or spleen weights.…”

Section: Discussionmentioning

confidence: 97%

The effect of coumarin on the liver weight of thermally injured rats

Piller

1976

Res. Exp. Med.

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“…Although there is some evidence to indicate that related benzopyrones are capable of stimulating cell proliferation in vitro (Huot et al, 1974), this has not been confirmed for coumarin in uivo. However there is evidence showing that drugs which increase phagocytic cell numbers produce increases in liver and spleen weights (Roos, 1970). Increased liver weights have also been reported following coumarin administration (Piller, 1976f).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Coumarin on Tissue Levels of Radio-Labelled Plasma Protein and Povidone (Polyvinylpyrrolidine) in Normal and Thermally Injured Rats

Piller

1976

Clin Exp Pharmacol Physiol

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1. The administration of coumarin resulted in a two-fold increase in the entry of 51Cr-labelled rat plasma protein into otherwise normal tissues. 2. Prior treatment of rats with coumarin allowed about 50% more radio-labelled protein to enter the tissues immediately after thermal injury than occurred with thermal injury in untreated rats. 3. In coumarin-treated rats, 30 min or more after thermal injury, tissue levels of 125I-labelled povidone (polyvinylpyrrolidine) were significantly elevated or showed no change compared with tissue levels in rats which received only thermal injury. 4. Conversely, tissue levels or radio-labelled protein in coumarin-treated rats, 30 min or more after thermal injury were significantly reduced to between 20 and 30% of those in untreated, thermally injured rats. 5. These results were attributed to enhanced proteolysis of the radio-labelled protein caused by coumarin. Other results have shown that normal protein is similarly affected. 6. The products of proteolysis may then rapidly leave the tissues, freeing the osmotically-held fluids and reducing the oedema.

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Makrophagen: Herkunft, Entwicklung und Funktion

Cited by 12 publications

References 502 publications

Excess plasma proteins as a cause of chronic inflammation and lymphoedema: Quantitative electron microscopy

Excess plasma proteins as a cause of chronic inflammation and lymphoedema: Quantitative electron microscopy

The effect of coumarin on the liver weight of thermally injured rats

The Influence of Coumarin on Tissue Levels of Radio-Labelled Plasma Protein and Povidone (Polyvinylpyrrolidine) in Normal and Thermally Injured Rats

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