This article discusses the role of clothing hygiene in the protection of healthcare workers. At the present stage of society's development, advanced innovative medical care has opened up new perspectives for the treatment of patients and allowed a gradual transition to predictive medicine that meets human needs. Today, there is a tendency to move from reactive to preventive and personalised medicine, based on the constant observance of personal hygiene. Personal hygiene plays an important role in preventing diseases and improving people's health. Prevention of infectious diseases has become one of the biggest challenges faced by all countries of the world.In most countries, healthcare-associated infections are one of the most common causes of illness. They continue to be a serious concern for hospitalised patients, increasing morbidity and even death. However, the spread of infection can be prevented by good hygiene practices. An important role in preventing the spread of hospital-acquired infections is played by medical clothing, which is the traditional work wear of healthcare professionals. Wearing it is mandatory, but not everyone remembers that this clothing has a great purpose -to protect medical staff and patients from dangerous diseases. Increasing evidence shows that healthcare worker clothing is often contaminated with microorganisms or pathogens that can cause infections or specific diseases. To successfully protect healthcare workers and patients, medical clothing must meet certain requirements. Its quality must meet hygienic standards, namely, it must be impermeable to liquids, easy to clean and sterilise, and have dirt-repellent properties. It must be made of durable fabrics, retain the appropriate quality and shape after repeated washing and be designed for longterm use, as well as be comfortable and hypoallergenic. The main requirements for special clothing for healthcare workers are its reliable protection and hygiene.Therefore, the use of technological innovations in everyday clothing and textiles can also prevent the ongoing endemic transmission of infection to patients. It is essential that manufacturers of medical clothing and other protective equipment develop textiles that reduce the acquisition, retention and transmission of infectious microorganisms in the blood, body fluids and environment.