2019
DOI: 10.1038/s41576-019-0160-0
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Making the case for more inclusive GWAS

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Cited by 9 publications
(7 citation statements)
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“…First, the analyses only included youth of European ancestry to match the original training sample for the GWAS-derived DEP-PRS, thereby limiting the extent to which current findings can be generalized to youth of other racial identities. As the vast majority of GWAS are limited to European samples (Duncan, Shen, et al, 2019), it is of vital importance that future GWAS include samples of increased racial diversity to allow for generalization of results to marginalized racial and ethnic populations (Clyde, 2019). Second, the current sample size is not large by the standards of genetic studies and may have been underpowered to detect smaller main or interaction effects.…”
Section: Discussionmentioning
confidence: 99%
“…First, the analyses only included youth of European ancestry to match the original training sample for the GWAS-derived DEP-PRS, thereby limiting the extent to which current findings can be generalized to youth of other racial identities. As the vast majority of GWAS are limited to European samples (Duncan, Shen, et al, 2019), it is of vital importance that future GWAS include samples of increased racial diversity to allow for generalization of results to marginalized racial and ethnic populations (Clyde, 2019). Second, the current sample size is not large by the standards of genetic studies and may have been underpowered to detect smaller main or interaction effects.…”
Section: Discussionmentioning
confidence: 99%
“…Genetic ancestry plays an important role in genetic studies, especially when the genetic architecture differs between samples and results obtained from one population may not generalize to others [53][54][55][56] . The detection of epistatic signals could be affected by the possible existence of complex higher-order (>2 SNPs) interactions, genetic heterogeneity, and varying patterns of genetic architecture 57 .…”
Section: Discussionmentioning
confidence: 99%
“…For example, in contrast to our expectations, we did not find an association with the score for coronary artery disease, which is a major cause of NCDs (Lloyd-Jones et al 2006). Another important limitation, which is endemic to the GWAS literature (Clyde 2019; Mills and Rahal 2019), is that we did not study individuals of non-European ancestry. Thus, we do not know whether our findings generalize to other ancestries (Martin et al 2019, 2017).…”
Section: Discussionmentioning
confidence: 99%