Making sense out of syngamy at the onset of mammalian development

Albertini, David F.

doi:10.1007/s10815-018-1282-6

Cited by 2 publications

(2 citation statements)

References 11 publications

(10 reference statements)

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“…This would be consistent with conditions such as mosaicism, chimerism, and mixoploidy, which frequently are observed after preimplantation genetic testing in the clinical practice of IVF. If confirmed, this finding raises the specter of a parental genome separation during the first cell cycle in the human embryo that would require rethinking our current concepts of syngamy [5]. This, in turn, could raise questions about when human life begins [6].…”

mentioning

confidence: 89%

Observation of two separate bipolar spindles in the human zygote

Zhang

et al. 2019

J Assist Reprod Genet

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confidence: 89%

Observation of two separate bipolar spindles in the human zygote

Zhang

et al. 2019

J Assist Reprod Genet

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“…Some of these scenarios may help to explain arrested syngamy which was not insignificant in our experiment, as 27.4% of the oocytes failed to become fertilized after sperm injection. In this context, it is interesting to recall Albertini’s [ 31 ] suggestion “Syngamy has become an acceptable sentinel for the beginning of life.” Clearly, there is a need to gain better knowledge of the haploid duties of both the oocyte and sperm cell to better understand syngamy failure.…”

Section: Discussionmentioning

confidence: 99%

Cumulus Cell DNA Damage as an Index of Human Oocyte Competence

Baratas

Gosálvez

Casa³

et al. 2021

Reprod. Sci.

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The determination of oocyte quality is crucial for achieving effective syngamy post-sperm injection and embryonic development. Cumulus cells (CCs) have been proposed as biomarkers of oocyte quality because of their close bio-dynamic relationship with the oocyte. To determine the quality of the oocyte, CCs were sampled during oocyte preparation for ICSI to determine a CC DNA fragmentation index (CCDFI) of each individual oocyte using a variant of the chromatin dispersion test. One hundred and thirty oocytes were selected and studied from two Spanish fertility clinics, 90 of which were fertilized and developed to embryos. Significant differences were found between the CCDFI of unfertilized and fertilized oocytes (p < .001) and between the CCDFI of embryos that were discarded and those that developed suitable for transfer or cryopreservation (p < .001). Oocyte quality was negatively correlated with CCDFI (Spearman’s rho = − 0.45; p < .001). Receiver operator characteristics curves (ROC) suggested that a cut-off value of 24% CCDFI was able to discriminate the capacity of the gametes to result in syngamy with a sensitivity and specificity of 75.6% and 65%, respectively. This cut-off supports the application of CCDFI as potential index for the evaluation of the reproductive potential of oocytes prior to fertilization.

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Making sense out of syngamy at the onset of mammalian development

Cited by 2 publications

References 11 publications

Observation of two separate bipolar spindles in the human zygote

Observation of two separate bipolar spindles in the human zygote

Cumulus Cell DNA Damage as an Index of Human Oocyte Competence

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