Making sense of chaos: uncovering the mechanisms of conformational entropy
Stephanie Wankowicz,
James Fraser
Abstract:During protein folding, proteins transition from a disordered polymer into a globular structure, markedly decreasing their conformational degrees of freedom and consequently leading to a substantial reduction in entropy. Nonetheless, folded proteins still retain significant entropy as they fluctuate between the conformations that make up their native state. This residual entropy contributes to crucial functions like binding or catalysis. Here, we outline three major ways that protein use conformational entropy… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.