Making sense of another mind: The role of the right temporo-parietal junction

Saxe, Rebecca; Wexler, Anna

doi:10.1016/j.neuropsychologia.2005.02.013

Cited by 852 publications

(645 citation statements)

References 57 publications

Supporting

Mentioning

563

Contrasting

Unclassified

Order By: Relevance

“…While the MCC has been shown to be involved in both self-and other-perspectives (Vogt, 2005), the bilateral STS and TPJ belong to the core neural network of mentalising ( Saxe and Wexler, 2005;Dodell-Feder et al, 2011). These latter two areas make up the network described by the cognitive neuroscience term "temporoparietal junction" (TPJ), known collectively to play a crucial role in self-other distinction processes, ToM, and the ability to make moral decisions (Saxe and Kanwisher, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…These results are consistent with neuropsychological deficits in patients with selective forms of brain damage. Damage to the right temporo-parietal junction is associated with a selective impairment of ToM, whereas damage to the medial prefrontal cortex is not (Saxe and Wexler, 2005). A within-subject comparison of reorienting and ToM paradigms revealed that both paradigms activated very similar temporo-parietal junction regions (Mitchell, 2008) implying that the temporo-parietal junction is also involved in non-social mental processes.…”

Section: Introductionmentioning

confidence: 90%

“…Saxe and Wexler (2005) found that enhanced activation in the right temporo-parietal junction was selective to the attribution of mental states, and was not recruited by processing other socially relevant facts about a person. Further, right temporo-parietal junction activity was enhanced when the protagonist of a story professed a belief or desire that was inconsistent with the subject's expectations, based on the protagonist's background (Saxe and Wexler, 2005). These results are consistent with neuropsychological deficits in patients with selective forms of brain damage.…”

Section: Introductionmentioning

confidence: 94%

“…During cognitive empathy processing, however, the BPD sample displayed decreased activation in both left superior temporal sulcus (STS) and gyrus (STG) (Dziobek et al, 2011). The insula is thought to be related to self-oriented emotion processing (Wicker et al, 2003;Jabbi et al, 2007;Craig, 2009;Singer et al, 2009), and the STS and STG are related to the ability to infer the mental states of others (Saxe and Wexler, 2005;Dodell-Feder et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dysregulation between emotion and theory of mind networks in borderline personality disorder

O’Neill

D'Souza

Samson

et al. 2015

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

a b s t r a c tIndividuals with borderline personality disorder (BPD) commonly display deficits in emotion regulation, but findings in the area of social cognitive (e.g., theory of mind, ToM) capacities have been heterogeneous. The aims of the current study were to investigate differences between patients with BPD and controls in functional connectivity (1) between the emotion and ToM network and (2) in the default mode network (DMN). Functional magnetic resonance imaging was used to investigate 19 healthy controls and 17 patients with BPD at rest and during ToM processing. Functional coupling was analysed. Significantly decreased functional connectivity was found for patients compared with controls between anterior cingulate cortex and three brain areas involved in ToM processes: the left superior temporal lobe, right supramarginal/inferior parietal lobes, and right middle cingulate cortex. Increased functional connectivity was found in patients compared with controls between the precuneus as the DMN seed and the left inferior frontal lobe, left precentral/middle frontal, and left middle occipital/ superior parietal lobes during rest. Reduced functional coupling between the emotional and the ToM network during ToM processing is in line with emotion-regulation dysfunctions in BPD. The increased connectivity between precuneus and frontal regions during rest might be related to extensive processing of internal thoughts and self-referential information in BPD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dysregulation between emotion and theory of mind networks in borderline personality disorder

O’Neill

D'Souza

Samson

et al. 2015

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

show abstract

“…Interestingly, a large body of evidence suggests that the TPJ is also involved in more abstract cognitive abilities, such as mind reading (Saxe & Wexler, 2005), theory of mind (Vogeley & Fink, 2003) and empathy (Decety & Lamm, 2007). All these functions imply a shift of perspective, from one's own cognitive or emotional point of view to that of another.…”

Section: The Body In the World: Self-locationmentioning

confidence: 99%

Bodily ownership and self-location: Components of bodily self-consciousness

Serino

Alsmith

Costantini

et al. 2013

Consciousness and Cognition

206

170

View full text Add to dashboard Cite

a b s t r a c tRecent research on bodily self-consciousness has assumed that it consists of three distinct components: the experience of owning a body (body ownership); the experience of being a body with a given location within the environment (self-location); and the experience of taking a first-person, body-centered, perspective on that environment (perspective). Here we review recent neuroimaging studies suggesting that at least two of these components-body ownership and self-location-are implemented in rather distinct neural substrates, located, respectively, in the premotor cortex and in the temporo-parietal junction. We examine these results and consider them in relation to clinical evidence from patients with altered body perception and work on a variety of multisensory, body-related illusions, such as the rubber hand illusion, the full body illusion, the body swap illusion and the enfacement illusion. We conclude by providing a preliminary synthesis of the data on bodily self-consciousness and its neural correlates.

show abstract

Self versus Others/Self‐Regulation

Krendl¹,

Heatherton²

2009

Handbook of Neuroscience for the Behavioral Sciences

View full text Add to dashboard Cite

Making sense of another mind: The role of the right temporo-parietal junction

Cited by 852 publications

References 57 publications

Dysregulation between emotion and theory of mind networks in borderline personality disorder

Dysregulation between emotion and theory of mind networks in borderline personality disorder

Bodily ownership and self-location: Components of bodily self-consciousness

Self versus Others/Self‐Regulation

Contact Info

Product

Resources

About