Making Organisms Model Human Behavior: Situated Models in North-American Alcohol Research, since 1950

Ankeny, Rachel A.; Leonelli, Sabina; Nelson, Nicole; Ramsden, Edmund

doi:10.1017/s0269889714000155

Cited by 41 publications

(23 citation statements)

References 110 publications

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“…Nestler and Hyman 2010). Social scientists and historians of science and medicine have provided rigorous analyses of the assumptions and constraints built into models of the environment (Ankeny et al 2014;Davies 2010;Ramsden 2011). How might these analyses be fed back into -and thereby refine -existing animal models?…”

Section: The Urban Brainmentioning

confidence: 99%

Rethinking Interdisciplinarity across the Social Sciences and Neurosciences

2015

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and Allan Young. We draw, occasionally, here on arguments, data and material that we have developed, in published and unpublished work and conference presentations, with some of those mentioned above; we are grateful for their generosity in allowing us to use (and abuse) these materials. We are enormously grateful to the funders who have supported interdisciplinary research across the social sciences, neurosciences and humanities, and whose workshops and grant schemes have been pivotal to the research that underpins this book. The Wellcome Trust, via its award to Hubbub to become the first residency of The Hub at Wellcome Collection, has been an extraordinary funder and interlocutor, and has been 10.1057/9781137407962-Rethinking Interdisciplinarity across the Social Sciences and Neurosciences, Felicity Callard and Des Fitzgerald

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Section: The Urban Brainmentioning

confidence: 99%

Rethinking Interdisciplinarity across the Social Sciences and Neurosciences

2015

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“…In this sense, laboratory animals may be more similar (at least in the relevant respects) to humans than they are to their counterparts in the wild. This point is well exemplified in the case study developed by Ankeny et al (2014). Ankeny and colleagues study animal model research on alcohol addiction in North America since the mid-twentieth century.…”

Section: Strengthening Reliability While Strengthening Validitymentioning

confidence: 90%

Validating Animal Models

Atanasova

2015

THEORIA

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This paper responds to a recent challenge for the validity of extrapolation of neurobiological knowledge from laboratory animals to humans. According to this challenge, experimental neurobiology, and thus neuroscience, is in a state of crisis because the knowledge produced in different laboratories hardly generalizes from one laboratory to another. Presumably, this is so because neurobiological laboratories use simplified animal models of human conditions that differ across laboratories. By contrast, I argue that maintaining a multiplicity of experimental protocols and simple models is well justified. It fosters rather than precludes the validity of extrapolation of neurobiological knowledge. The discipline is thriving.Keywords: Animal Models, Calibration, Validity, Reliability, Experimental Neurobiology.RESUMEN: Este artículo responde a un reto reciente: la validez de extrapolar el conocimiento neurobiológico del laboratorio animal a los humanos. Según esta objeción la neurobiología experimental, y por ende la neurociencia, está en crisis porque el conocimiento obtenido en los laboratorios de neurobiología utiliza modelos animales simplificados de las condiciones humanas que difieren de unos laboratorios a otros. Por el contrario, sostengo que mantener una diversidad de protocolos experimentales y de modelos simples está sobradamente justificado. Favorece, en vez de impedir, la validez de la extrapolación de conocimiento neurobiológico. La neurobiología es una disciplina floreciente.

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“…The environment of the animal plays an important role in the behavioral sciences, either as part of the background of controlled conditions that make experimental manipulations visible, as part of the justification for the resemblance of animal models to human disorders, or as a topic of inquiry in its own right (Ankeny et al, 2014). Handling, housing and other kinds of difference-generating interactions between the animal and its environment are by no means absent from the field's own scientific concerns, and yet the field's relationship to animal care is no less problematic.…”

Section: Relationships Between Science and Welfare In The Neurosciencmentioning

confidence: 99%

Model homes for model organisms: Intersections of animal welfare and behavioral neuroscience around the environment of the laboratory mouse

Nelson

2015

BioSocieties

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This article investigates the environment of the laboratory animal as a site where animal welfare and behavioral neuroscience intersect, creating opportunities for cross-pollinations between the concepts and practices of each field. Laboratory animal welfare is organized around a distinction between the care of animals and their use in experiments, and while best practices for animal handling and the management of animal housing may appear to fall firmly within the ambit of animal care, behavioral researchers' own histories of work on 'experimenter effects' and 'enriched environments' complicate this distinction. Using historical and ethnographic data from animal behavioral neuroscience laboratories, this article examines how welfare professionals have drawn on behavioral science as a source of new data and techniques, and how researchers in turn employ concepts from animal welfare in their scientific thinking. This investigation provides insight into how changes in animal welfare oversight are changing scientific practice, but it also reveals one reason why taking seriously the idea of the animal as a situated, interactive being in laboratory practice remains difficult. Professional conflicts over the management of the animal's environment and rhetorical troubles created by the association of gene-environment interaction research with welfare agendas complicate both the management and meaning of interaction in the animal behavioral neuroscience laboratory.

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Making Organisms Model Human Behavior: Situated Models in North-American Alcohol Research, since 1950

Cited by 41 publications

References 110 publications

Rethinking Interdisciplinarity across the Social Sciences and Neurosciences

Rethinking Interdisciplinarity across the Social Sciences and Neurosciences

Validating Animal Models

Model homes for model organisms: Intersections of animal welfare and behavioral neuroscience around the environment of the laboratory mouse

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