Making “Good” Choices: Social Isolation in Mice Exacerbates the Effects of Chronic Stress on Decision Making

Rakshasa, Arish Mudra; Tong, Michelle

doi:10.3389/fnbeh.2020.00081

Cited by 22 publications

(15 citation statements)

References 66 publications

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“…For example, although LABORAS can be used to characterize behavioral changes in several disease models, this system can only track a single mouse per cage during an experiment. Isolation of mice may affect their general well-being, physical activity, and behaviors, such as body weight 59 , stress 60 , and cognitive performance 61 because mice are social creatures. In addition, social isolation may contribute to the translation of behavioral pain because pain modulation in mice can be influenced by social factors 59 , 62 .…”

Section: Discussionmentioning

confidence: 99%

Automated home-cage for the evaluation of innate non-reflexive pain behaviors in a mouse model of inflammatory pain

Hasriadi

Wasana

Vajragupta

et al. 2021

Sci Rep

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The failure to develop analgesic drugs is attributed not only to the complex and diverse pathophysiology of pain in humans but also to the poor experimental design and poor preclinical assessment of pain. Although considerable efforts have been devoted to overcoming the relevant problems, many features of the behavioral pain assessment remain to be characterized. For example, a decreased locomotor activity as a common presentation of pain-like behavior has yet to be described. Studies on mice experimentally induced with carrageenan have provided opportunities to explore pain-related behaviors in automated home-cage monitoring. Through this approach, the locomotor activities of mice with carrageenan-induced inflammatory pain can be precisely and objectively captured. Here, we found that the mobile behaviors of mice reduced, and their immobility increased, indicating that carrageenan induction in mice caused a significant decrease in locomotor activity. These non-reflexive pain behaviors were strongly correlated with the reflexive pain behaviors measured via von Frey and plantar tests. Furthermore, the pharmacological intervention using indomethacin improved the locomotor activity of mice with carrageenan-induced pain. Thus, the analysis of the locomotor activity in automated home-cage monitoring is useful for studying the behavioral analgesia and the pharmacological screening of analgesic drugs. The combined evaluation of reflexive and non-reflexive pain behaviors enhances the translational utility of preclinical pain research in rodents.

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Section: Discussionmentioning

confidence: 99%

Automated home-cage for the evaluation of innate non-reflexive pain behaviors in a mouse model of inflammatory pain

Hasriadi

Wasana

Vajragupta

et al. 2021

Sci Rep

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“…How closely these models reflect the human stress response is unclear, but the hormonal responses mimic those observed in humans, and even factors such as social support (housing with other animals) reduce the stress response very much like that seen in humans. 23 Even the witnessing of traumatic events of other animals activates the stress response like in humans. 24 A number of studies have examined lower urinary tract function in these animal models of stress and found bladder dysfunction is a common outcome following a stress protocol.…”

Section: Animal Models Of Psychological Stressmentioning

confidence: 99%

Chronic psychological stress and lower urinary tract symptoms

Chess-Williams

McDermott

Sellers

et al. 2021

LUTS

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It is well established that lower urinary tract symptoms (LUTS), particularly urinary urgency and incontinence, cause stress and anxiety for patients. However, there is mounting evidence that the relationship between these two factors is bidirectional and that chronic psychological stress itself can result in the development of symptoms such as urinary frequency, urgency, incontinence, and pelvic pain. This review considers the evidence that such a relationship exists and reviews the literature from clinical and animal studies to identify some of the mechanisms that might be involved. Inflammatory responses induced by chronic stress appear to offer the strongest link to bladder dysfunction. There is overwhelming evidence, both in patients and animal models, for a release of pro-inflammatory cytokines and chemokines during periods of chronic stress. Furthermore, cytokines have been shown to cause bladder dysfunction and pain via actions in the central nervous system and locally in the bladder. In the brain and spinal cord, pro-inflammatory cytokines influence the regulation of micturition pathways by corticotropin-releasing factor (CRF) and its receptors, while peripherally cytokines affect bladder function, directly causing detrusor hypertrophy and afferent nerve hypersensitivity. There is little information on which treatments may have most benefit for stressed/anxious patients with LUTS, but animal studies suggest traditional drugs for overactive bladder (solifenacin, mirabegron) are more effective on LUTS than anxiolytic drugs (fluoxetine, imipramine). The preliminary preclinical data for CRF receptor antagonists is not consistent. A clearer understanding of the mechanisms involved in stress-induced LUTS should provide a basis for improved treatment of this condition.

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“…For example, in female mice, individual housing appears to increase plasma corticosterone and anxiety levels in the elevated plus maze assay [ 153 ] and in a modified open-field test [ 150 ], compared to females living in group housing. In contrast, individually housed males were not a affected, and their levels of anxiety and plasma corticosterone did not differ from group-housed controls [ 150 , 154 , 155 , 156 ]. Socially isolated adult female mice also displayed increased immobility in the forced-swim and tail-suspension tests, indicating depression-like symptoms [ 157 ], while similar effects in males were induced only when isolation occurred throughout adolescence [ 158 ] or after prolonged isolation [ 127 , 144 , 159 , 160 ].…”

Section: Sex Differences In the Response To Social Isolationmentioning

confidence: 99%

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Zilkha

Sofer

Kashash

et al. 2021

Current Opinion in Neurobiology

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Social animal species present a vast repertoire of social interactions when encountering conspecifics. Reproduction-related behaviors, such as mating, parental care, and aggression, are some of the most rewarding types of social interactions and are also the most sexually dimorphic ones. This review focuses on rodent species and summarizes recent advances in neuroscience research that link sexually dimorphic reproductive behaviors to sexual dimorphism in their underlying neuronal circuits. Specifically, we present a few possible mechanisms governing sexually-dimorphic behaviors, by hypothalamic and reward-related brain regions. Sex differences in the neural response to social isolation in adulthood are also discussed, as well as future directions for comparative studies with naturally solitary species.

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Making “Good” Choices: Social Isolation in Mice Exacerbates the Effects of Chronic Stress on Decision Making

Cited by 22 publications

References 66 publications

Automated home-cage for the evaluation of innate non-reflexive pain behaviors in a mouse model of inflammatory pain

Automated home-cage for the evaluation of innate non-reflexive pain behaviors in a mouse model of inflammatory pain

Chronic psychological stress and lower urinary tract symptoms

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

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