Making Biomedical Sciences publications more accessible for machines

Meenen, Joris Van; Leysen, Hanne; Chen, Hongyu; Baccarne, Rudi; Walter, Deborah; Martin, Bronwen; Maudsley, Stuart

doi:10.1007/s11019-022-10069-0

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…While the pathophysiology of aging can be described via a convergence of multiple signaling mechanisms, an orthogonal mechanism of defining aging can be achieved using latent semantic analyses of millions of peer-reviewed documents available at PMC/NCBI to create a user-defined molecular signature of aging [ 201 , 202 , 203 ]. Using multiple latent semantic analyzer applications (GLAD4U [ 204 ], PubPular [ 205 ], Geneshot [ 206 ]), a user-defined descriptive list of proteins was defined.…”

Section: Functional Gpr19 Molecular Signaturesmentioning

confidence: 99%

Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process

Maudsley

Walter

Schrauwen

et al. 2022

IJMS

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G protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes of transmembrane proteins. GPCRs and their associated signaling systems have been linked to nearly every physiological process. They also constitute nearly 40% of the current pharmacopeia as direct targets of remedial therapies. Hence, their place as a functional nexus in the interface between physiological and pathophysiological processes suggests that GPCRs may play a central role in the generation of nearly all types of human disease. Perhaps one mechanism through which GPCRs can mediate this pivotal function is through the control of the molecular aging process. It is now appreciated that, indeed, many human disorders/diseases are induced by GPCR signaling processes linked to pathological aging. Here we discuss one such novel member of the GPCR family, GPR19, that may represent an important new target for novel remedial strategies for the aging process. The molecular signaling pathways (metabolic control, circadian rhythm regulation and stress responsiveness) associated with this recently characterized receptor suggest an important role in aging-related disease etiology.

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Section: Functional Gpr19 Molecular Signaturesmentioning

confidence: 99%

Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process

Maudsley

Walter

Schrauwen

et al. 2022

IJMS

Self Cite

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“…Apart from such topics of interdisciplinary co-work and human-machine interaction, there are more points to consider if "argumentative digital bioethics" is going to succeed as a scientific enterprise: Technical issues relate, for example, to the necessities of making academic publications better accessible for machines in terms of interoperability, so that relevant literature can undergo (semi-) automated screening and further processing. 50 A closer look at the digital humanities coupled with a bit of imagination opens up a wide range of methodological options for "argumentative digital bioethics" for research, development, and the application of tools (see Table 1).…”

Section: Argumentative Digital Bioethicsmentioning

confidence: 99%

The birth of the “digital turn” in bioethics?

Salloch

Ursin

2022

Bioethics

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The so‐called “empirical turn” in bioethics gave rise to extensive theoretical and methodological debates and has significantly shaped the research landscape from two decades ago until the present day. Attentive observers of the evolution of the bioethical research field now notice a new trend towards the inclusion of data science methods for the treatment of ethical research questions. This new research domain of “digital bioethics” encompasses both studies replacing (or complementing) socio‐empirical research on bioethical topics (“empirical digital bioethics”) and argumentative approaches towards normative questions in the healthcare domain (“argumentative digital bioethics”). This article draws on insights taken from the debate on the “empirical turn” for sounding out perspectives for the newly developing field of “digital bioethics.” We particularly discuss the disciplinary boundaries, chances and challenges, and potentially undesirable developments of the research field. The article closes with concrete suggestions on which debates need to be initiated and which measures need to be taken so that the path forward of “digital bioethics” will be a scientific success.

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Medicine and machines

Have

Gordijn

2022

Med Health Care and Philos

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Making Biomedical Sciences publications more accessible for machines

Cited by 3 publications

References 62 publications

Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process

Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process

The birth of the “digital turn” in bioethics?

Medicine and machines

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