“…During tissue morphogenesis, the presence of specific growth factors guides cells behaviour; thus, they also govern neo-tissue formation and organization (Smith, 2003). As such, they play a central role in controlling cell behaviour and activity in dental tissue repair and regeneration (Butler and Ritchie, 1995;Nakashima and Reddi, 2003;Smith, 2003;Silva et al, 2004;Nakashima, 2005;Zhang et al, 2005b;Goldberg et al, 2006). Many growth factors are quite versatile and can stimulate cellular division in numerous cell types, while others may demonstrate a degree of specificity in terms of the cells they act upon (Tziafas, 2004).…”