2005
DOI: 10.1038/sj.cr.7290299
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Making a tooth: growth factors, transcription factors, and stem cells

Abstract: Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-mesenchymal interactions. These processes involve a series of inductive and permissive interactions that result in the determination, differentiation, and organization of odontogenic tissues. Multiple signaling molecules, including BMPs, FGFs, Shh, and Wnt proteins, have been implicated in mediating these tissue interactions. Transcription factors participate in epithelial-mesenchymal interactions via linking the signaling… Show more

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Cited by 274 publications
(267 citation statements)
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“…Molecular studies of mice odontogenesis have demonstrated that a number of Wnt genes are expressed in the developing teeth and that changes in their expression may be one of the factors determining tooth agenesis (Zhang et al 2005). The first evidence for a crucial role of the Wnt pathway in odontogenesis comes from the functional analysis of Lef1.…”
Section: Resultsmentioning
confidence: 99%
“…Molecular studies of mice odontogenesis have demonstrated that a number of Wnt genes are expressed in the developing teeth and that changes in their expression may be one of the factors determining tooth agenesis (Zhang et al 2005). The first evidence for a crucial role of the Wnt pathway in odontogenesis comes from the functional analysis of Lef1.…”
Section: Resultsmentioning
confidence: 99%
“…5 Another important family of protein is found in enamel knot signaling center, that is Tumor Necrosis Factor family, which has been studied in Tabby, Downless and Crinkled mutant mice where size and number of molar cusps are significantly reduced with missing incisors and molars. 9,10 Tissue recombination technique: understanding odontogenesis…”
Section: Tooth Morphogenesismentioning
confidence: 99%
“…During tissue morphogenesis, the presence of specific growth factors guides cells behaviour; thus, they also govern neo-tissue formation and organization (Smith, 2003). As such, they play a central role in controlling cell behaviour and activity in dental tissue repair and regeneration (Butler and Ritchie, 1995;Nakashima and Reddi, 2003;Smith, 2003;Silva et al, 2004;Nakashima, 2005;Zhang et al, 2005b;Goldberg et al, 2006). Many growth factors are quite versatile and can stimulate cellular division in numerous cell types, while others may demonstrate a degree of specificity in terms of the cells they act upon (Tziafas, 2004).…”
Section: Growth Factorsmentioning
confidence: 99%
“…During tooth development, sequential and reciprocal epithelial-mesenchymal interactions involve a series of inductive and permissive interactions that result in the determination, differentiation and organization of odontogenic tissues. Multiple signalling molecules, BMPs, FGFs, Sonic hedgehog (Shh) and Wnt proteins, have been implicated as mediators of these tissue interactions (Zhang et al, 2005b). A careful examination of the literature indicates that the transforming growth factor (TGF)-β family and BMPs are important in cellular signalling for odontoblast differentiation and stimulation of dentine matrix secretion and are hence essential for pulp regeneration (Chan et al, 2005;Liu et al, 2007).…”
Section: Growth Factorsmentioning
confidence: 99%
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