Making a new limb out of old cells: exploring endogenous cell reprogramming and its role during limb regeneration
Michael J. Raymond,
Catherine D. McCusker
Abstract:Cellular reprogramming is characterized by the induced dedifferentiation of mature cells into a more plastic and potent state. This process can occur through artificial reprogramming manipulations in the lab such as nuclear reprogramming and iPSC generation, and endogenously in vivo during amphibian limb regeneration. In amphibians such as the Mexican axolotl, a regeneration permissive environment is formed by nerve-dependent signaling in the wounded limb tissue. When exposed to these signals, limb connective … Show more
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