Making a COVID-19 vaccine that works for everyone: ensuring equity and inclusivity in clinical trials

Pepperrell, Toby; Rodgers, Florence; Tandon, Pranav; Sarsfield, Kelly; Pugh-Jones, Molly; Rashid, Theo; Keestra, Sarai

doi:10.1080/16549716.2021.1892309

Cited by 18 publications

(16 citation statements)

References 21 publications

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“…The impact of COVID-19 in this population can be understood not only from a biological perspective but also regarding social or economic factors, with certain communities being more predisposed to suffering from poorer outcomes [ 74 ]. This is a critical issue to address, as a recent study found that only 25 out of 219 clinical trials have taken place in lower-middle or low-income countries, and up to 80% of the people recruited in active vaccination trials were not from ethnic minorities, leading to an underrepresentation of these populations [ 75 ]. Thus, it is imperative to also include these populations as a priority group for vaccination.…”

Section: Strategies and Considerations In Covid-19 Vaccination Programsmentioning

confidence: 99%

An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times

et al. 2021

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Since the worldwide COVID-19 pandemic was declared a year ago, the search for vaccines has become the top priority in order to restore normalcy after 2.5 million deaths worldwide, overloaded sanitary systems, and a huge economic burden. Vaccine development has represented a step towards the desired herd immunity in a short period of time, owing to a high level of investment, the focus of researchers, and the urge for the authorization of the faster administration of vaccines. Nevertheless, this objective may only be achieved by pursuing effective strategies and policies in various countries worldwide. In the present review, some aspects involved in accomplishing a successful vaccination program are addressed, in addition to the importance of vaccination in a pandemic in the face of unwillingness, conspiracy theories, or a lack of information among the public. Moreover, we provide some updated points related to the landscape of the clinical development of vaccine candidates, specifically, the top five vaccines that are already being assessed in Phase IV clinical trials (BNT162b2, mRNA-1273, AZD1222, Ad26.COV2.S, and CoronaVac).

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Section: Strategies and Considerations In Covid-19 Vaccination Programsmentioning

confidence: 99%

An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times

et al. 2021

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“…As regards the principle of justice in connection with vaccinations, the first issue relates to equity in vaccine trial programs [ 20 , 21 ], and the second pertains to the agreements which make financing for research dependent on the supply of a certain number of vaccine doses [ 22 , 23 ]. The third issue concerns the distribution of the vaccines themselves.…”

Section: Covid-19 Pandemic and Equal Access To Treatment And Vaccinationmentioning

confidence: 99%

COVID-19 Pandemic and Equal Access to Vaccines

et al. 2021

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The COVID-19 pandemic has evidenced the chronic inequality that exists between populations and communities as regards global healthcare. Vaccination, an appropriate tool for the prevention of infection, should be guaranteed by means of proportionate interventions to defeat such inequality in populations and communities affected by a higher risk of infection. Equitable criteria of justice should be identified and applied with respect to access to vaccination and to the order in which it should be administered. This article analyzes, as regards the worldwide distribution of anti-COVID-19 vaccines, the various ways the principle of equity has been construed and applied or even overlooked. The main obstacle to equal access to vaccines is vaccine nationalism. The perception of equity varies with the differing reference values adopted. Adequate response to needs appears to be the principal rule for achieving the criterion of equity in line with distributive justice. Priorities must be set equitably based on rational parameters in accordance with current needs. The entire process must be governed by transparency, from parameter identification to implementation. The issue of equal access to vaccination affects the entire world population, necessitating specific protective interventions. In light of this, the World Health Organization (WHO) has devised the COVAX plan to ensure that even the poorest nations of the world receive the vaccine; certain initiatives are also supported by the European Union (EU). This pandemic has brought to the fore the need to build a culture of equitable relationships both in each country’s own domain and with the rest of the world.

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“…Therefore, the vaccination process cannot ignore the concept of equity as it is interpreted in the health domain. Research in PubMed with the query “(equity [Title]) AND (COVID-19)” showed that the problem of equity is strongly perceived from different points of view, starting from the ethics up to the social vision [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ].…”

Section: The Digital Divide the Escape The Exposure Risk The Equitymentioning

confidence: 99%

The Vaccination Process against the COVID-19: Opportunities, Problems and mHealth Support

Simeoni¹,

Maccioni

Giansanti

2021

Healthcare

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The vaccination against the COVID-19, finally available, has the potential to represent an important defence against the pandemic. The identification of both obstacles and tools to combat them are, at this moment, of strategic importance. Previous experiences on vaccinations have shown solutions and paths to take, also based on the behavioural sciences. The objective of the opinion is to face how mobile technology can help us both to fight these problems and to optimize the vaccination process. The opinion has four polarities. The first polarity consists in having detected the problems hampering an effective vaccination process. These problems have been grouped into the following four: Electronic and Informatic divide, Escape, Exposure risk, and Equity. The second polarity consists in having verified how the mobile technology can be useful to face the identified problems. The third polarity highlights the usefulness and importance of using electronic surveys. These tools are based on mobile technology. They are useful problem sensors for the stakeholders. The fourth polarity faces how mobile technology and mHealth can be of aid to optimize the flow of the vaccination process, from the first call up to the certification. This polarity is supported by an example based on the Italian national App IO. The study highlights: (a) on one side, the potential of mobile technology; on the other side, the need for interventions to reduce the digital divide with the purpose to increase its use. (b) How the role of mobile technology can be complementary to other intervention methods.

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Making a COVID-19 vaccine that works for everyone: ensuring equity and inclusivity in clinical trials

Cited by 18 publications

References 21 publications

An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times

An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times

COVID-19 Pandemic and Equal Access to Vaccines

The Vaccination Process against the COVID-19: Opportunities, Problems and mHealth Support

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