Making a case for endovascular approaches for neural recording and stimulation

Thielen, Brianna; Xu, Huijing; Fujii, Tatsuhiro; Rangwala, Shivani D; Jiang, Wenxuan; Lin, Michelle; Kammen, Alexandra; Liu, Charles; Selvan, Pradeep; Song, Dong; Mack, William J.; Meng, Ellis

doi:10.1088/1741-2552/acb086

Cited by 3 publications

(2 citation statements)

References 69 publications

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“…However, traditional invasive electrode placement methods like ECoG and SEEG come with a range of complications, such as hematoma, infection, and bloodbrain barrier disruption. 7 Moreover, these methods are not suitable for covering large areas, limiting the collection of neural signals both in terms of scope and invasiveness. Long-term electrode implantation can lead to issues such as scarring, infection, and even epilepsy.…”

Section: Endovascular Signal Detection Technologies the Advantage Of ...mentioning

confidence: 99%

The brain nebula: minimally invasive brain–computer interface by endovascular neural recording and stimulation

He,

Yang,

et al. 2024

J NeuroIntervent Surg

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A brain–computer interface (BCI) serves as a direct communication channel between brain activity and external devices, typically a computer or robotic limb. Advances in technology have led to the increasing use of intracranial electrical recording or stimulation in the treatment of conditions such as epilepsy, depression, and movement disorders. This indicates that BCIs can offer clinical neurological rehabilitation for patients with disabilities and functional impairments. They also provide a means to restore consciousness and functionality for patients with sequelae from major brain diseases. Whether invasive or non-invasive, the collected cortical or deep signals can be decoded and translated for communication. This review aims to provide an overview of the advantages of endovascular BCIs compared with conventional BCIs, along with insights into the specific anatomical regions under study. Given the rapid progress, we also provide updates on ongoing clinical trials and the prospects for current research involving endovascular electrodes.

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Section: Endovascular Signal Detection Technologies the Advantage Of ...mentioning

confidence: 99%

The brain nebula: minimally invasive brain–computer interface by endovascular neural recording and stimulation

He,

Yang,

et al. 2024

J NeuroIntervent Surg

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“…Endovascular recording of brain waves in millimeter-scale blood vessels has been demonstrated in previous studies (13)(14)(15). Endovascular EEG in humans (16) was first achieved using a guided stainless-steel catheter with a 1.5 mm × 0.6 mm electrode.…”

mentioning

confidence: 97%

Ultraflexible endovascular probes for brain recording through micrometer-scale vasculature

Zhang

Mandeville

et al. 2023

Science

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Implantable neuroelectronic interfaces have enabled advances in both fundamental research and treatment of neurological diseases but traditional intracranial depth electrodes require invasive surgery to place and can disrupt neural networks during implantation. We developed an ultrasmall and flexible endovascular neural probe that can be implanted into sub-100-micrometer–scale blood vessels in the brains of rodents without damaging the brain or vasculature. In vivo electrophysiology recording of local field potentials and single-unit spikes have been selectively achieved in the cortex and olfactory bulb. Histology analysis of the tissue interface showed minimal immune response and long-term stability. This platform technology can be readily extended as both research tools and medical devices for the detection and intervention of neurological diseases.

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Fabrication of Biomedical Electrodes Using Printing Approaches

Rajbhandari,

Nattestad,

Liu

et al. 2024

Biomedical Materials & Devices

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In this review, we focus on the fabrication of electrodes, using printing techniques. Generally speaking, electrodes are comprised of a metal conductor with a metal lead (sometimes the same material) for the conduction of electrical current. Different inorganic and organic materials including metal, polymers, carbon, as well as their composites thereof, have been used for electrodes on different substrates. While material-dependent characteristics, including conductivity, optical transparency, corrosion resistance and biocompatibility, determine the choice of material, printing, as the manufacturing method, offers precise control over the geometry and scale of electrodes for selective and sensitive performance. Both 2D- and 3D-printed electrodes have been widely used as sensors for electrochemical applications as well as quantification of biological compounds, establishing contact with biological surfaces and systems, finding application in medical diagnosis, therapy and treatment of various conditions. Costa et al. (Energy Storage Mater 28:216–234, 2020), Mensing et al. (Sustain Mater Technol 25:e00190, 2020) depict the difference between the 2D and 3D printing techniques which can be used for fabrication of 2D and 3D electrodes. The 3D structure of the electrode provides advantages over the 2d electrodes in terms of its catalytic properties through enhancement in its mass transfer process, adsorption efficiency and active exposure sites (Mensing et al. in Sustain Mater Technol 25:e00190, 2020).

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Making a case for endovascular approaches for neural recording and stimulation

Cited by 3 publications

References 69 publications

The brain nebula: minimally invasive brain–computer interface by endovascular neural recording and stimulation

The brain nebula: minimally invasive brain–computer interface by endovascular neural recording and stimulation

Ultraflexible endovascular probes for brain recording through micrometer-scale vasculature

Fabrication of Biomedical Electrodes Using Printing Approaches

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