We investigate Majorana dark matter in a new variant of Uð1Þ L μ −L τ gauge extension of the Standard Model, where the scalar sector is enriched with an inert doublet and a (3, 1, 1=3) scalar leptoquark. We compute the weakly interacting massive particle-nucleon cross section in the leptoquark portal and the relic density mediated by inert doublet components, the leptoquark, and the new Z 0 boson. We constrain the parameter space consistent with the Planck limit on the relic density and the PICO-60 and LUX bounds on the spin-dependent direct detection cross section. Furthermore, we constrain the new couplings from the present experimental data on Brðτ → μν τ ν μ Þ, BrðB → X s γÞ, BrðB 0 → K 0 μ þ μ − Þ, BrðB þ → K þ τ þ τ − Þ, and B s − B s mixing, which occur at the one-loop level in the presence of the Z 0 and leptoquark. Using the allowed parameter space, we estimate the form-factor-independent P 0 4;5 observables and the lepton nonuniversality parameters R K , R K Ã , and R ϕ. We also briefly discuss neutrino mass generation at the oneloop level and the viable parameter region to explain current neutrino oscillation data.