Major Trends in Cancer:25 Year Survey

Silverberg, B S Edwin; Holleb, Arthur I.

doi:10.3322/canjclin.25.1.2

Cited by 47 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…31 Phillips et al had 23% hospital mortality for large bowel obstruction caused by colon carcinoma. 37 Many other reports have shown higher postoperative mortality related to emergency admission.. 19,[37][38][39] The unfavorable effects of advanced age and tumor stage on hospital mortality were clearly showed in previous reports, 34,39,40 as well as our study. The mean age of our patients who died after operation was 72.3 years.…”

Section: Discussionsupporting

confidence: 79%

Colorectal carcinoma in poor blacks

Freeman

Alshafie

2002

Cancer

View full text Add to dashboard Cite

BACKGROUNDDeath rates for most cancers continue to be higher for African Americans, particularly those in inner cities. Harlem Hospital serves a poor, predominantly African‐American community in New York City.METHODSTumor registry records for 615 patients treated for colorectal carcinoma at Harlem Hospital between 1973 and 1992 were reviewed.RESULTSOf the patients, 45.2% were male and 54.8% female, 97.2% were black, and 82% resided in Harlem. All patients were symptomatic at the time of diagnosis;15.3% were first diagnosed intraoperatively; 8.4% were in American Joint Committee on Cancer Stage I, 20.8% Stage II, 22.8% Stage III, 39.0% Stage IV, and 8.0% could not be staged. Colon resection with intention of cure was performed on 50.6%, 21.5% had palliative resection, and 11.6% had colostomy or other palliative surgery. Adjuvant chemotherapy or radiotherapy was given to 6.2%; 16.9% had no surgical treatment because of advanced stage, poor condition, or refusal of surgery; 12.7% presented with perforation or intestinal obstruction. Operative mortality was 15.3% overall and 10.6% for 311 patients who had surgery with intention of cure. Twenty‐five patients had local recurrence, 86 had subsequent distant metastases, and 33 patients had both local and distant recurrence. Forty‐nine patients (8%) were lost to follow‐up. The 5‐year crude survival rate for 615 patients was 18.7%. The relative survival rate was 19.7%, substantially lower than the national average for the same years.CONCLUSIONSAlthough colorectal carcinoma mortality continues to decline nationally, in this population of poor blacks the mortality rate remained high and unchanged. The most important cause of this is late presentation at an incurable stage, resulting from the combined effects of poverty, lack of education, and lack of access to primary care. Culturally sensitive educational programs and accessible health care systems for the poor are needed. Cancer 2002;94:2327–32. © 2002 American Cancer Society.DOI 10.1002/cncr.10486

show abstract

Section: Discussionsupporting

confidence: 79%

Colorectal carcinoma in poor blacks

Freeman

Alshafie

2002

Cancer

View full text Add to dashboard Cite

show abstract

“…3,4,6 These rates differ markedly from the 800 per million in Saudi Arabia. The Middle East may be less cancerogenic: the death rate from all cancers per million population (combining males and females) in 1989 was 1300 in Kuwait but 1770 in the United States.…”

mentioning

confidence: 84%

“…As another reference point, the number of all cancers in the United States in 1989 was 1,010,000 or 4200 per million, and the relative frequency of thyroid cancer among the total cancers was then 1.2%. 4 The relative frequency for 1975 was also calculated at 1.2%, 3 but was considerably lower in 1970 at 0.4%. 6 The sharp rise in incidence and relative frequency of thyroid cancer before 1975 was probably related to the injudicious use of radiation therapy that had been administered in the years before 1960.…”

mentioning

confidence: 99%

The Increasing Incidence of Thyroid Cancer in Saudi Arabia

Sisson

1995

Annals of Saudi Medicine

View full text Add to dashboard Cite

“…Colon cancer has a very high incidence in humans, especially in Western cultures (Silverberg and Holleb, 1975). On the other hand, the incidence of tumors of the small intestine is extremely low (Silverberg and Holleb, 1975).…”

Section: Introductionmentioning

confidence: 99%

Selective inhibition of replicative and repair DNA synthesis in mouse colon following administration of 1,2‐dimethylhydrazine

Koval

1984

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

Early alterations in normal semiconservative and repair DNA synthesis were determined in gastrointestinal tissues of HalCR mice following administration of the colon carcinogen 1,2-dimethylhydrazine (DMH). Following DMH injections of 60 and 200 mg/kg, normal DNA synthesis was rapidly inhibited in all tissues. The greatest depressions were observed in the descending colon, followed closely by the ascending colon. DNA repair was estimated by measuring unscheduled DNA synthesis. No repair was observable in the descending or ascending colon. The esophagus, forestomach, jejunum, and ileum demonstrated significant amounts of DNA repair, while the duodenum and gastric stomach displayed nominal or insignificant amounts of repair. Repair DNA synthesis was inhibited by simultaneous administration of caffeine and DMH. The degree of inhibition of normal replicative DNA synthesis and the amount of repair DNA synthesis in response to DMH treatment correlate closely with the incidence of DMH-induced tumors. Most tumors occur in the descending colon, followed by the ascending colon, and only a few in the duodenum and gastric stomach area. Neoplasms are rarely found in the remainder of the gastrointestinal system.

show abstract

Major Trends in Cancer:25 Year Survey

Cited by 47 publications

References 0 publications

Colorectal carcinoma in poor blacks

Colorectal carcinoma in poor blacks

The Increasing Incidence of Thyroid Cancer in Saudi Arabia

Selective inhibition of replicative and repair DNA synthesis in mouse colon following administration of 1,2‐dimethylhydrazine

Contact Info

Product

Resources

About