2000
DOI: 10.1016/s0002-9610(99)00253-6
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Major surgery increases serum levels of vascular endothelial growth factor only temporarily

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Cited by 34 publications
(18 citation statements)
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“…Concomitantly, levels of angiostatin and endostatin in urine and plasma, respectively, dropped. Moreover, others demonstrated that serum VEGF was markedly elevated after surgery, especially during the first days after resection [81][82][83][84]. Taken together, these findings suggest that surgery may cause a switch in the angiogenic balance.…”
Section: Angiogenesis Inhibitors and Surgerymentioning
confidence: 83%
“…Concomitantly, levels of angiostatin and endostatin in urine and plasma, respectively, dropped. Moreover, others demonstrated that serum VEGF was markedly elevated after surgery, especially during the first days after resection [81][82][83][84]. Taken together, these findings suggest that surgery may cause a switch in the angiogenic balance.…”
Section: Angiogenesis Inhibitors and Surgerymentioning
confidence: 83%
“…Since 1993 Kim found blocking the expression of VEGF acting in blood vascular system could significantly inhibit the growth of tumor, an increasing number of researches showed that the level of VEGF reflexed the proliferation, migration and blood vessel construction of tumor endothelial cell and directly reflected the growth speed and metastasis of tumor (Bondestam et al, 2000). Shan et al (Shan et al, 2004) suggested that the positive expression rate of VEGF in esophageal cancer tissues was 70.9% and the expression of VEGF was associated with pathology classification, depth of invasion and lymphatic metastasis, which provide the theoretical foundation for the treatment of esophageal cancer by blocking the expression of VEGF.…”
Section: Discussionmentioning
confidence: 99%
“…The effect of surgical intervention on VEGF levels has been examined, and major surgery for nonmalignant disease induced the highest transient VEGF increase on POD 1 [23]. Maniwa et al [24] also showed that pulmonary surgery induced VEGF elevation temporarily in patients with metastatic lung cancer.…”
Section: Discussionmentioning
confidence: 99%