Major Risk Factors Analysis of Pruritus Complicated by Type 2 Diabetes Mellitus and the Effect of Comprehensive Nursing Intervention

Yang, Qiu; Chen, Yuan Yuan; Li, Zhenzhen; Xu, Mingming

doi:10.3389/fsurg.2022.842884

Cited by 4 publications

(9 citation statements)

References 31 publications

(34 reference statements)

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“…IFN-γ levels were relatively high in chronic AD skin lesions and patients with DM ( 10 , 17 ). However, in a study with 224 patients with type 2 DM, IFN-γ levels were not significantly higher among patients with pruritus vs those without pruritus ( 8 ), similar to our results. IL-31 is a crucial cytokine that contributes to pruritus of AD and has been reported to be elevated in many pruritic skin diseases ( 18 – 21 ).…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies have noted different risk factors for diabetic pruritus ( 8 , 13 ). Stefaniak et al ( 3 ) reported a significantly higher fasting plasma glucose level in patients with type 2 DM with pruritus than in those without pruritus.…”

Section: Discussionmentioning

confidence: 97%

“…Regarding comorbidities, diabetic neuropathy is commonly considered to cause diabetic pruritus ( 3 , 8 ). The current results reveal that underlying comorbidities, such as hypertension, hyperlipidaemia, diabetic neuropathy, or cardio-cerebrovascular diseases, were not significantly correlated with diabetic pruritus.…”

Section: Discussionmentioning

confidence: 99%

“…However, the effects of these antipruritic therapies are often insufficient, because the pathophysiology of chronic pruritus in patients with DM is poorly understood. Studies have reported that postprandial blood glucose ( 7 ), fasting plasma glucose ( 3 , 8 ), age, duration of DM, diabetic neuropathy, diabetic retinopathy, and diabetic kidney disease ( 8 ) are associated with diabetic pruritus. Nevertheless, results from different studies are inconsistent and occasionally contradictory.…”

mentioning

confidence: 99%

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Serum Mediators in Patients with Both Type 2 Diabetes Mellitus and Pruritus

Hsu

Chen

et al. 2023

Acta Derm Venereol

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Chronic pruritus is an unpleasant sensory perception that negatively affects quality of life and is common among patients with type 2 diabetes mellitus. Current antipruritic therapies are insufficiently effective. Thus, the mediation of diabetic pruritus by histamine-independent pathways is likely. The aim of this study was to identify possible mediators responsible for diabetic pruritus. A total of 87 patients with type 2 diabetes mellitus were analysed, of whom 59 had pruritus and 28 did not. The 2 groups were assessed for baseline demographics, serum biochemistry parameters, cytokines, and chemokines. This study also investigated the associations of these factors with the severity of itching. Neither haemoglobin A1c nor serum creatinine levels were correlated with severity of itching. Significantly higher levels of interleukin-4 (p = 0.004), interleukin-13 (p = 0.006), granulocyte-macrophage colony-stimulating factor (p < 0.001) and C-X-C motif chemokine ligand 10 (p = 0.028) were observed in the patients with pruritus than in those without pruritus. Moreover, the levels of these mediators were positively correlated with the severity of itching. Thus, novel antipruritic drugs can be developed to target these molecules. This is the first study to compare inflammatory mediators comprehensively in patients with diabetes mellitus with pruritus vs those without pruritus.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Serum Mediators in Patients with Both Type 2 Diabetes Mellitus and Pruritus

Hsu

Chen

et al. 2023

Acta Derm Venereol

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“…296 Advanced age and long disease duration are also risk factors for pruritus. 297 in dosage; co-administration with carbamazepine accelerates its metabolism, significantly reducing its hypoglycemic effect. 298 Vildagliptin used in combination with ACEIs may increase the risk of angioneurotic edema.…”

Section: Tumorsmentioning

confidence: 99%

Guideline for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition)

Guo,

Xiao

2024

Aging Medicine

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With the deepening of aging in China, the prevalence of diabetes in older people has increased noticeably, and standardized diabetes management is critical for improving clinical outcomes of diabetes in older people. In 2021, the National Center of Gerontology, Chinese Society of Geriatrics, and Diabetes Professional Committee of Chinese Aging Well Association organized experts to write the first guideline for diabetes diagnosis and treatment in older people in China, the Guideline for the Management of Diabetes Mellitus in the Elderly in China (2021 Edition). The guideline emphasizes that older patients with diabetes are a highly heterogeneous group requiring comprehensive assessment and stratified and individualized management strategies. The guideline proposes simple treatments and de‐intensified treatment strategies for older patients with diabetes. This edition of the guideline provides clinicians with practical and operable clinical guidance, thus greatly contributing to the comprehensive and full‐cycle standardized management of older patients with diabetes in China and promoting the extensive development of clinical and basic research on diabetes in older people and related fields. In the past 3 years, evidence‐based medicine for older patients with diabetes and related fields has further advanced, and new treatment concepts, drugs, and technologies have been developed. The guideline editorial committee promptly updated the first edition of the guideline and compiled the Guideline for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition). More precise management paths for older patients with diabetes are proposed, for achieving continued standardization of the management of older Chinese patients with diabetes and improving their clinical outcomes.

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The Effectiveness of Massage and Virgin Coconut Oil (VCO) Combination Therapy on Reducing Itching in Diabetes Mellitus

Zamroni,

Sutawardana,

Kushariyadi

et al. 2023

jkki

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Diabetic pruritus is a skin complication that is often found in diabetes mellitus patients which is characterized by complaints of itching. One of the complementary therapies that can reduce itching is to do massage and VCO combination therapy. The study aim to analyze the effectiveness of combination massage therapy and VCO to reduce itching in diabetic. This research is a descriptive study using a case study approach. Participant in this study was patient with type II diabetes mellitus with complaints of itchy skin. The intervention was carried out for 3 days of treatment with a frequency of action twice a day in the morning and evening after bathing. The pre-test and post-test were assessed using two instruments including the Overall Dry Skin Score (ODSS) to assess the dryness of the patient's skin and the Itch Numeric Rating Scale (Itch NRS) to assess the patient's itch level. The results showed a decrease in the level of skin dryness from the scale 3 to scale 2 on day 3 of treatment and there was a decrease in the itching scale from scale 7 to scale 4 on day 3 of treatment. Combination therapy of massage and VCO can increase the level of skin moisture as evidenced by a decrease in the level of skin dryness so that it will also reduce the level of skin itching. With these results, it can be considered to make combination massage therapy and VCO as therapeutic modality to overcome the problem of itching in DM patients.

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Major Risk Factors Analysis of Pruritus Complicated by Type 2 Diabetes Mellitus and the Effect of Comprehensive Nursing Intervention

Cited by 4 publications

References 31 publications

Serum Mediators in Patients with Both Type 2 Diabetes Mellitus and Pruritus

Serum Mediators in Patients with Both Type 2 Diabetes Mellitus and Pruritus

Guideline for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition)

The Effectiveness of Massage and Virgin Coconut Oil (VCO) Combination Therapy on Reducing Itching in Diabetes Mellitus

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