Major Publications in the Critical Care Pharmacotherapy Literature: 2020

Abstract

OBJECTIVES: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2020. DATA SOURCES: The Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update group screened 36 journals monthly for impactful publications. STUDY SELECTION: The group reviewed a total of 119 articles during 2020 according to relevance for practice. DATA EXTRACTION: Articles were selected with consensus and importance to clinical practice from those included in the monthly Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update. The group reviewed articles according to Grading of Recommendations, Assessment, Development, and Evaluations criteria. Articles with a 1A grade were selected. DATA SYNTHESIS: Several trials were summarized, including two meta-analyses and five original research trials. Original research trials evaluating vitamin C, hydrocortisone, and thiamine versus hydrocortisone in sepsis, the use of nonsedation strategies, dexmedetomidine in cardiac surgery, remdesivir for severe acute respiratory syndrome coronavirus 2, and thrombectomy in acute ischemic stroke. Two meta-analyses determining the impact of norepinephrine initiation in patients with septic shock and the use of corticosteroids in severe acute respiratory syndrome coronavirus 2 was included. CONCLUSIONS: This clinical review provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2020.

Major Publications in the Critical Care Pharmacotherapy Literature: 2022

“…To mitigate information overload, strategies have been used to keep up with literature including journal surveillance, interaction with scientific and media communities, and services to journals including article review and editorial work (3). The Clinical Pharmacy and Pharmacology Literature Update (CPPLU) working group within the Society of Critical Care Medicine reviews major critical care journals, distributes a monthly summary to various sections of the Society, and reviews influential articles relevant to critical care pharmacotherapy annually (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Therefore, we aimed to summarize the most influential publications related to the pharmacotherapeutic care of critically ill patients in 2022.…”

Major Publications in the Critical Care Pharmacotherapy Literature: 2021

“…This has left clinicians and researchers with an unrealistic quantity of new knowledge to review and synthesize, often relying on alternative strategies to stay up to date such as social media, webinars, podcasts, and journal clubs, among others (2). The Clinical Pharmacy and Pharmacology Literature Update working group in the Society of Critical Care Medicine, Section on Clinical Pharmacy and Pharmacology, reviews major critical care journals and provides synopses to its members on a monthly basis in addition to an annual review of most impactful articles relevant to critical care pharmacotherapy from the year (3)(4)(5)(6)(7)(8)(9)(10)(11). Our objective was to identify the most impactful pharmacotherapy articles published in 2021 as it relates to critical care and provide synopses of these articles with their relevance to bedside care.…”