Major Patterns in Vertebrate Evolution.

Schuh, Randall T.; Hecht, Max K.; Goody, Peter C.; Hecht, Bessie M.

doi:10.2307/2412989

Cited by 3 publications

(1 citation statement)

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“…We first obtained the amino acid sequences of 5 immunoglobulins within the human V regions [32] and converted these into mRNA sequences [33]. The letters X, S, T, Y, Z, R and H were replaced by degenerate letters according to IUPAC [34].…”

Section: Computing Gd Palindromes In Protein Sequencesmentioning

confidence: 99%

Comparing Degenerate Strings

Alzamel

Ayad

Bernardini

et al. 2020

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Uncertain sequences are compact representations of sets of similar strings. They highlight common segments by collapsing them, and explicitly represent varying segments by listing all possible options. A generalized degenerate string (GD string) is a type of uncertain sequence. Formally, a GD string Ŝ is a sequence of n sets of strings of total size N, where the ith set contains strings of the same length ki but this length can vary between different sets. We denote by W the sum of these lengths k0, k1, . . . , kn-1. Our main result is an 𝒪(N + M)-time algorithm for deciding whether two GD strings of total sizes N and M, respectively, over an integer alphabet, have a non-empty intersection. This result is based on a combinatorial result of independent interest: although the intersection of two GD strings can be exponential in the total size of the two strings, it can be represented in linear space. We then apply our string comparison tool to devise a simple algorithm for computing all palindromes in Ŝ in 𝒪(min{W, n2}N)-time. We complement this upper bound by showing a similar conditional lower bound for computing maximal palindromes in Ŝ. We also show that a result, which is essentially the same as our string comparison linear-time algorithm, can be obtained by employing an automata-based approach.

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Section: Computing Gd Palindromes In Protein Sequencesmentioning

confidence: 99%