“…Second, hnRNPs A1, A2-B1, D and E and hnRNP homologous proteins from other organisms can associate with the single stranded telomeric repeat sequence in vivo (Dallaire et al, 2000;Ding et al, 1999;Erlitzki and Fry, 1997;Ishikawa et al, 1993;Johnston et al, 1999;McKay and Cooke, 1992;Sarig et al, 1997). Third, hnRNPs including those found to associate with telomerase and telomeres are integral components of the nuclear matrix (Gallinaro et al, 1983;Gohring and Fackelmayer, 1997;Mattern et al, 1996Mattern et al, , 1997Mattern et al, , 1999van Eekelen and van Venrooij, 1981;Weighardt et al, 1999). The nuclear matrix is a putative attachment site for telomeres making it possible that hnRNPs and telomeres are in close proximity if not directly associated (de Lange, 1992;Luderus et al, 1996;Smilenov et al, 1999).…”