Major Histocompatibility Locus in the Arabian Horse

Vd, Mottironi; Le, Perryman; Pollara, Bernard; Mr, Mickey; Swift, Ronnie Gorman; McGrath, P. F.

doi:10.1097/00007890-198104000-00011

Cited by 11 publications

(4 citation statements)

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“…However, an antibody to ELY-2.1 might have some effect on a newborn foal. Antibodies to ELA antigens have been detected in colostrum (Lkzary et al 1980a), and in the sera of young foals (Mottironi et al, 1981). Presumably, this antibody was acquired passively by the foal through ingestion of colostrum (Jeffcott, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…Lymphocyte alloantigen polymorphisms of the horse have been the subject of several recent investigations. Most of these investigations have focused on the equine lymphocyte antigen (ELA) system, which is believed to be the major histocompatibility complex (MHC) of the horse (Lizary et al, 1980a, b;Mottironi et al, 1981;Antczak et al, 1982;Bailey, 1983). Early descriptions of a complex genetic organization of the ELA region detectable by cytotoxic antisera (Bailey, 1980;Lazary et al, 1980a), have not yet been confirmed at the level of international workshops on the ELA system (Bull, 1983;.…”

Section: Introductionmentioning

confidence: 99%

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Lymphocyte alloantigens of the horse. III. ELY‐2.1: a lymphocyte alloantigen not coded for by the MHC

Antczak

1984

Animal Blood Groups and Biochemical Genetics

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Summary A new polymorphic locus of the horse which has several unusual properties is described. The suggested name for the locus is ELY‐2. The gene product of one allele at this locus, designated ELY‐2.1, has been identified with antisera raised as a result of pregnancy. Antibody to ELY‐2.1 was first detected on day 55 after conception in the serum of a mare in first pregnancy. This early onset of antibody is similar to that seen for antibody to ELA antigens, and suggests that the source of the antigenic stimulus may be the tissue of the equine endometrial cups. The antisera identifying ELY‐2.1 are cytotoxic and kill all peripheral blood lymphocytes from horses carrying the antigen. ELY‐2.1 is a cell surface molecule expressed on lymphocytes, erythrocytes, and platelets. Other cell types have not been investigated. The overall phenotypic frequency of ELY‐2.1 in several horse breeds was 16 %. The ELY‐2.1 antigen is controlled by an autosomal, dominant gene which is not coded by the ELA region (the major histocompatibility complex of the horse), nor is it identical to the ELY‐1 locus, which codes for another cell surface alloantigen of equine lymphocytes. Stimulator cells carrying ELY‐2.1 did not induce proliferation of ELY‐2.1 negative responder cells in mixed cultures of horse lymphocytes. Attempts to raise alloantisera to other alleles of the ELY‐2 locus through immunization with lymphocytes were unsuccessful. It is possible that the alternate allele(s) does not code for a gene product which is expressed. The function and biochemical nature of the ELY‐2.1 molecule are unknown.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lymphocyte alloantigens of the horse. III. ELY‐2.1: a lymphocyte alloantigen not coded for by the MHC

Antczak

1984

Animal Blood Groups and Biochemical Genetics

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“…The realisation that studies involving leucocyte antigens and the definition of the MHC of the horse may be of considerable potential value has been marked by a recent explosion of interest in this field of research (Lazary, de Weck, Straub and Gerber 1975;Bright, Antczak and Ricketts 1978;de Weck et al 1978;Lazary 1979;Bailey, Stormont, Suzuki and Trommerhausen-Smith 1979;Bailey 1980;Lazary et a1 1980a, b;Mottironi et al 1981;Antczak, Bright, Remick and Bauman 1982;Bailey 1983a, b;Antczak 1984;Bailey and Henney 1984).…”

Section: International Workhops On Lymphocyte Alloantigens In the Horsementioning

confidence: 99%

Equine leucocyte antigen system: Progress and potential

Matthews

1985

Equine Veterinary Journal

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Summary Leucocyte antigens are cell‐surface glycoproteins, the structure of which is under the genetic control of a chromosome region called the major histocompatibility complex. Progress in the study of the equine leucocyte antigen (ELA) system has been achieved in two ways; first by the fact that the ELA system is intensively investigated in different laboratories all over the world and parallels can be drawn to the information gained from research in more extensively studied species, and secondly by the collaborative efforts of the participants in three international workshops. The potential applications of the ELA system and areas of further investigation are discussed.

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“…Lymphocyte alloantigens in horses were characterized initially by Lazary et al (1975) and Schmid, Cwik & Emerich (1975). Since then, several laboratories have performed serological and genetic studies on the major histocompatibility complex (MHC) of the horse (Bailey, 1980;Lazary et al, 1980a, b;Mottironi et al, 1981;Antczak et al, 1982). During the first international workshop on equine lymphocyte alloantigens (ELA) (Bull, 1983) an international nomenclature was accepted defining 6 allelic ELA specificities called ELA-W1, W2, W3, W4, W5 and W6.…”

Section: Introductionmentioning

confidence: 99%

Equine lymphocyte antigens in four major Belgian horse populations. Contribution to serology and antigen distribution

Varewyck

Bouquet

Lazàry

et al. 1985

Animal Blood Groups and Biochemical Genetics

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158 Belgian Saddlebreds, 130 Belgian Trotters, 108 Belgian Draft horses and 92 Shetland ponies have been typed for serologically defined antigens at the ELA and ELY systems. Gene frequencies were estimated in each breed for the internationally established ELA, ELY-1 and ELY-2 alleles as well as for locally assigned additional ELA markers and for subtypes of ELA-W3, W9 and W11. The distribution of ELA alleles was in agreement with the expected Hardy-Weinberg equilibrium for the 4 horse breeds described here. Differences in gene frequencies between these main Belgian horse populations were observed.

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Major Histocompatibility Locus in the Arabian Horse

Cited by 11 publications

References 0 publications

Lymphocyte alloantigens of the horse. III. ELY‐2.1: a lymphocyte alloantigen not coded for by the MHC

Lymphocyte alloantigens of the horse. III. ELY‐2.1: a lymphocyte alloantigen not coded for by the MHC

Equine leucocyte antigen system: Progress and potential

Equine lymphocyte antigens in four major Belgian horse populations. Contribution to serology and antigen distribution

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