Major Histocompatibility Complex Variation in Talas Tuco-Tucos: The Influence of Demography on Selection

Cutrera, A; Lacey, Eileen A.

doi:10.1644/05-mamm-a-383r1.1

Cited by 24 publications

(28 citation statements)

References 87 publications

(146 reference statements)

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“…Population structure and MHC Mating behaviour as a correlate and driver of social structure has been suggested in addition to pathogens as another main subject of selection on MHC loci in natural populations (Hambuch and Lacey, 2002;Kundu and Faulkes, 2004;Cutrera and Lacey, 2006). Animals form social groups and colonies in response to cooperative interactions as well as mating tactics.…”

Section: Evidence For Historical Selectionmentioning

confidence: 99%

“…Genes of the MHC are known to alter the individual body odour (for example, Penn and Potts, 1998;Milinski, 2006;Kwak et al, 2009) and may therefore be involved in mate choice decisions (for example, Wedekind et al, 1995;Chaix et al, 2008;Ilmonen et al, 2009), thus promoting genetic structure within and among social groups (Chesser, 1990;Kundu and Faulkes, 2004;Matocq and Lacy, 2004;Cutrera and Lacey, 2006). Sexual selection processes may not only be supported in direct mate choice situations but also through postcopulatory mechanisms including maternal-fetal interactions (for example, Wedekind et al, 1996;Ober and Van der Ven, 1997).…”

Section: Introductionmentioning

confidence: 99%

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MHC class II DRB diversity, selection pattern and population structure in a neotropical bat species, Noctilio albiventris

et al. 2011

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Genes of the major histocompatibility complex (MHC) have a crucial role in the immune response of vertebrates, alter the individual odour and are involved in shaping mating preferences. Pathogen-mediated selection, sexual selection and maternal-fetal interactions have been proposed as the main drivers of frequently observed high levels of polymorphism in functionally important parts of the MHC. Bats constitute the second largest mammalian order and have recently emerged as important vectors of infectious diseases. In addition, Chiroptera are interesting study subjects in evolutionary ecology in the context of olfactory communication, mate choice and associated fitness benefits. Thus, it is surprising that they belong to the least studied mammalian taxa in terms of their MHC diversity. In this study, we investigated the variability in the functionally important MHC class II gene DRB, evidence for selection and population structure in the group-living lesser bulldog bat, Noctilio albiventris, in Panama. We found a single expressed, polymorphic Noal-DRB gene. The substitution pattern of the nucleotide sequences of the 18 detected alleles provided evidence for positive selection acting above the evolutionary history of the species in shaping MHC diversity. Roosting colonies were not genetically differentiated but females showed lower levels of heterozygosity than males, which might be a sign that the sexes differ in the selection pressures acting on the MHC. This study provides the prerequisites for further investigations of the role of the individual MHC constitution in parasite resistance, olfactory communication and mate choice in N. albiventris and other bats.

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Section: Evidence For Historical Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MHC class II DRB diversity, selection pattern and population structure in a neotropical bat species, Noctilio albiventris

et al. 2011

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“…Genes within the MHC that are involved in antigen presentation are usually highly polymorphic, and those polymorphic sites are mainly confined to the codons forming the peptidebinding region (PBR) (Piertney and Oliver, 2006). It has been documented that MHC gene diversity is usually affected by many ecological factors, such as population bottlenecks, demographics, environment, and social structure (Piertney and Oliver, 2006;Cutrera and Lacey, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…An increasing number of studies have examined diversity at MHC class II loci in different species so as to investigate the ecological repercussions of this diversity on resistance to parasites (Bernatchez and Landry, 2003). The second exon has been shown to be highly polymorphic and under positive selection, and the class II DQA gene has recently attracted more attention (Bryja et al, 2006;Cutrera and Lacey, 2006;Amills et al, 2008;Goüy et al, 2009). In artiodactyls, research on the DQ gene structure and polymorphisms of economically important animals such as cattle and sheep is remarkably extensive (Ballingall et al, 1997;Hickford et al, 2000Hickford et al, , 2004Zhou and Hickford, 2004).…”

Section: Introductionmentioning

confidence: 99%

Insight into gene evolution within Cervidae and Bovidae through genetic variation in MHC-DQA in the black muntjac (Muntiacus crinifrons)

Tong

Li²,

Luo³

2012

Genet. Mol. Res.

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ABSTRACT. The critical role that the major histocompatibility complex plays in the immune recognition of parasites and pathogens makes its evolutionary dynamics exceptionally relevant to ecology, population biology, and conservation studies. The black muntjac is a rare deer endemic to a small mountainous region in eastern China. We found that this species has two DQA loci through cDNA expression and sequence variation analysis. The level of variation at both DQA loci was found to be extremely low (three alleles for DQA1 and four alleles for DQA2), possibly because of past bottlenecks and the species' relatively solitary behavior pattern. The ratio of d N /d S in the putative peptide binding region of the DQA2 locus (13.36, P = 0.012) was significantly larger than one but not that of DQA1 (0.94, P = 0.95), suggesting strong positive selection at the DQA2 but not at the DQA1 locus. This difference might reflect different sets of evolutionary selection pressures acting on the two loci. The phylogenetic tree showed that DQA1 alleles from two species of Cervidae and two of Bovidae grouped together, as did the DQA2 alleles. However, different genes from the four species were located in separate branches. These results lead us to suggest that these DQA alleles are derived from primordial DQA genes ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (3): 2888-2898 (2012) Genetic variation of MHC-DQA in black muntjac 2889 from a common ancestor and are maintained in Cervidae and Bovidae since their divergence around 25.5-27.8 million years ago.

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“…However, the patterns of genetic diversity at the DQA locus in our study were-for the most part-qualitatively similar to DQA diversity in other wild mammals. For instance, compared to elephants, more alleles per study subject were observed in wild baboons and Weddell seals (Alberts 1999;, while fewer alleles were found in Ross seals, leopard seals, elephant seals, marmosets, and tuco tucos (Antunes et al 1998;Cutrera and Lacey 2006;Weber et al 2004). However, the African DQA locus in our study differed from other studies of wild mammals in that one allele was especially common.…”

Section: Discussionmentioning

confidence: 99%

Major histocompatibility complex variation and evolution at a single, expressed DQA locus in two genera of elephants

et al. 2010

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Genes of the vertebrate major histocompatibility complex (MHC) are crucial to defense against infectious disease, provide an important measure of functional genetic diversity, and have been implicated in mate choice and kin recognition. As a result, MHC loci have been characterized for a number of vertebrate species, especially mammals; however, elephants are a notable exception. Our study is the first to characterize patterns of genetic diversity and natural selection in the elephant MHC. We did so using DNA sequences from a single, expressed DQA locus in elephants. We characterized six alleles in 30 African elephants (Loxodonta africana) and four alleles in three Asian elephants (Elephas maximus). In addition, for two of the African alleles and three of the Asian alleles, we characterized complete coding sequences (exons 1-5) and nearly complete non-coding sequences (introns 2-4) for the class II DQA loci. Compared to DQA in other wild mammals, we found moderate polymorphism and allelic diversity and similar patterns of selection; patterns of non-synonymous and synonymous substitutions were consistent with balancing selection acting on the peptides involved in antigen binding in the second exon. In addition, balancing selection has led to strong trans-species allelism that has maintained multiple allelic lineages across both genera of extant elephants for at least 6 million years. We discuss our results in the context of MHC diversity in other mammals and patterns of evolution in elephants.

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Major Histocompatibility Complex Variation in Talas Tuco-Tucos: The Influence of Demography on Selection

Cited by 24 publications

References 87 publications

MHC class II DRB diversity, selection pattern and population structure in a neotropical bat species, Noctilio albiventris

MHC class II DRB diversity, selection pattern and population structure in a neotropical bat species, Noctilio albiventris

Insight into gene evolution within Cervidae and Bovidae through genetic variation in MHC-DQA in the black muntjac (Muntiacus crinifrons)

Major histocompatibility complex variation and evolution at a single, expressed DQA locus in two genera of elephants

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