Major histocompatibility complex, t-complex, and leukemia

Dorak, MT; Burnett, AK

doi:10.1007/bf00124261

Cited by 22 publications

(11 citation statements)

References 80 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The t complex of genes, which confers cancer susceptibility, is transferred preferentially through fathers in a phenomenon called segregation distortion. 18 The t complex contains both TCP-1 and MnSOD, both of which were identified in this study. Figueroa et al 19 proposed that since Mn SOD is a mitochondrial enzyme, and mitochondria are important for sperm motility, MnSOD is in fact the gene within the t complex that is responsible for the observed segregation distortion.…”

Section: Figurementioning

confidence: 63%

“…24 In this chromosomal region there are genes for two disorders, in addition to ALS, and two commonly elicited signs in sufferers, that co-segregate in some families with schizophrenia (Table 2). Therefore, heterogenous rearrangement of, deletions in, or abnormal regulation of genes within the chromosomal region [16][17][18][19] segregation distortion…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia

et al. 2000

View full text Add to dashboard Cite

Comparative brain proteome analysis is a new strategy to discover proteins and therefore genes whose altered expression may underlie schizophrenia. This strategy does not require an a priori theory of the pathogenesis or the mode of inheritance of schizophrenia. Using proteome analysis we previously compared the hippocampal proteome, that is, those proteins expressed by the hippocampal genome, of seven schizophrenic individuals with the hippocampal proteome of seven control individuals, matched for age and post mortem delay. 1 We found 18 proteins that were significantly altered in concentration in the schizophrenic hippocampus (P Ͻ 0.05), when compared to control tissue. One of these proteins was characterised, by N-terminal sequencing, as diazepam binding inhibitor whose gene maps to 6q12-q21. Here we characterise a further three of the 18 proteins as: manganese superoxide dismutase, 6q25.3, T-complex protein 1, 6q25.3-q26 and collapsin response mediator protein 2, 8p21. That three of these four characterised proteins should map to the long arm of the same chromosome is significant (P Ͻ 0.002) and suggests the importance of chromosome 6q in schizophrenia. These results indicate that antioxidant defence is altered in the schizophrenic hippocampus and suggest that segregation distortion, of schizophrenia susceptibility genes, may be a possible causative factor in the high incidence of schizophrenia. Molecular Psychiatry (2000) 5, 85-90.

show abstract

Section: Figurementioning

confidence: 63%

Section: Figurementioning

confidence: 99%

Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia

et al. 2000

View full text Add to dashboard Cite

show abstract

“…It is surprising that this fact has been frequently overlooked in similar association studies of human leukaemia. In view of the findings in animal models, previous human studies in leukaemia, and the recessive nature of the putative leukaemia susceptibility gene(s) within the MHC (Dorak and Burnett, 1992), HLA association studies in human cancer should investigate the frequencies of genotypes including homozygous ones. If homozygosity had been examined, the previously observed significant but relatively weak DR53 association in CLL (Dyer et al, 1986) might have been stronger.…”

Section: Discussionmentioning

confidence: 99%

Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia

et al. 1996

Self Cite

View full text Add to dashboard Cite

The major histocompatibility complex is one of the interactive factors in the multifactorial model of carcinogenesis. Its main influence in experimental models is on the age at onset of malignancies. We have previously shown a similar effect of homozygosity for HLA-DR53 in CML. In the present study, we investigated 79 patients with CLL and 329 local controls from Germany. In addition to full serotyping, all patients and I I 6 of controls were also typed by HU-DR6 PCR analysis. The homozygosity rates for DR53 in patients under and over the median age (60 years) were 18.6% and 2.9%, respectively ( p = 0.03). In experimental models, the major histocompatibility complex (MHC) has an interactive influence on the development of spontaneous, virally or chemically-induced malignancies (Lilly et al., 1964; Boyse et al., 1972;Faraldo et al., 1979;Oomen et al., 1988;Vasmel et al., 1988). Particular alleles of this polymorphic system influence the incidence and phenotype, as well as the age at onset of malignancies (Vasmel et al., 1988;Miyazawa et al., 1992). The interaction of the MHC is not exerted on transformation of a neoplastic clone but occurs during the pre-leukaemic stage (Chesebro, 1981;Lonai et al., 1982). Thus, it does not contain essential susceptibility genes but influences the rate of progression to overt malignancy. More than one MHC gene is involved in the complex, multifactorial development of malignancies (Oomen et al., 1988;Zijlstra and Melief, 1986). Eight of theThe findings in animal models stimulated similar studies investigating the role of the human MHC (HLA complex) in malignancies. The initial serological studies uncovered some associations but did not establish a strong and consistent influence of HLA antigens on the development of neoplasms (Tiwari and Terasaki, 1985). The haemopoietic malignancies have been the most extensively studied ones (Seremetis et al., 1985;Bortin et al., 1987;Caruso et al., 1987;Richter et al., 1973;Nunez-Roldan et al., 1982; Kilpatrick et al., 1984;Dyer et al., 1986;Cuttner et al., 1994). In leukaemia and lymphoma also, no consistent HLA association has been shown by serology.With the advent of molecular typing methods, this issue has been revisited. Recent studies have shown stronger allelic associations, although genotypes, age and gender effect have usually been overlooked (Apple et al., 1994;Klitz et al., 1994). The first DNA-based study investigating the role of the HLA complex in the development of leukaemia showed a strong influence of several independent genotypes on the age at onset of chronic myeloid leukaemia (CML), the strongest one being homozygosity for the supertypic specificity HLA-DR53 (Dorak et al., 1994a). A second molecular study confirmed the role of this homozygous genotype in increased susceptibility to childhood acute lymphoblastic leukaemia (ALL) and also showed a gender effect (Dorak et al., 1995).In the present study, the same association and its influence on the age at onset of chronic lymphoid leukaemia (CLL) were investigated by DNA analy...

show abstract

“…The first study on HLA in human leukemia demonstrated an increased frequency of HLA-A2 in ALL in 1967 .From that date many previous studies have demonstrated some significant differences in HLA allele frequencies in leukemic patients and normal subjects which had reported by Diase et al (2015) and others (14,15,16). In our study, significant positive association with the disease, in patients compared to controls, was found for two alleles: HLA-DRB1*013.Also there were moderate difference among DRB1*06 DRB1*14, and *15.…”

Section: Discussion:-mentioning

confidence: 87%

“…Diase et al (2015) had reported that HLA-DRB1*13, which showed a decrease in patients, should be protective against ALL (14). The findings that were demonstrated also by Dorak et al (2013),who reported that the frequency of the HLA-DRB1*13 allele was lower in male patients of leukemia (15).…”

Section: Discussion:-mentioning

confidence: 94%

Do Gamma Rays of Cancer Radiotherapy Effect on the Sequence of Collagenase Gene?

Mousa¹,

Awwad²,

Ali³

et al. 2017

IJAR

View full text Add to dashboard Cite

Major histocompatibility complex, t-complex, and leukemia

Cited by 22 publications

References 80 publications

Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia

Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia

Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia

Do Gamma Rays of Cancer Radiotherapy Effect on the Sequence of Collagenase Gene?

Contact Info

Product

Resources

About