Major hepatic resections in infancy and childhood

Howat, J M

doi:10.1136/gut.12.3.212

Cited by 22 publications

(6 citation statements)

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“…Biliary complications after partial liver resection occur in 5-29 % of the children [11,12,17,23]. If the injury is recognized during the surgical procedure, it can be repaired immediately.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of childhood hepatoblastoma in the Netherlands (1990–2013)

et al. 2016

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Background Achievement of complete surgical resection plays a key role in the successful treatment of children with hepatoblastoma. The aim of this study is to assess the surgical outcomes after partial liver resections for hepatoblastoma, focusing on postoperative complications, resection margins, 30-day mortality, and long-term survival. Method Chart reviews were carried out on all patients treated for hepatoblastoma in the Netherlands between 1990 and 2013. Results A total of 103 patients were included, of whom 94 underwent surgery. Partial hepatectomy was performed in 76 patients and 18 patients received a liver transplant as a primary procedure. In 42 of 73 (58 %) patients, one or more complications were reported. In 3 patients, information regarding complications was not available. Hemorrhage necessitating blood transfusion occurred in 33 (45 %) patients and 9 (12 %) patients developed biliary complications, of whom 8 needed one or more additional surgical interventions. Overall, 5-year disease-specific survival was 82, 92 % in the group of patients who underwent partial hepatectomy, and 77 % in the group of patients who underwent liver transplantation. Conclusions Partial hepatectomy after chemotherapy in children with hepatoblastoma offers good chances of survival. This type of major surgery is associated with a high rate of surgical complications (58 %), which is not detrimental to survival.

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Section: Discussionmentioning

confidence: 99%

Surgical treatment of childhood hepatoblastoma in the Netherlands (1990–2013)

et al. 2016

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“…After major hepatic resections, complications such as bile leak, biliary strictures, bleeding, coagulopathy, blood flow to and though the liver obstruction, liver failure and infection may be encountered [19] , [20] . Therefore patients must be closely monitored post-operatively in a paediatrics critical care unit for the first few days to anticipate, prevent and treat possible clinical deterioration.…”

Section: Discussionmentioning

confidence: 99%

Hepatoblastoma in childhood, long term survival achieved: 2 case reports and literature review

Asmar

Rassi

2016

International Journal of Surgery Case Reports

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HighlightsHepatoblastoma is the most common primary liver tumor for children under 5 years of age, with an incidence of 5.2 per million.Diagnosis depends on imaging studies, AFP levels and percutaneous biopsy.Treatment modality is usually surgical with neoadjuvant chemotherapy.Remission and long term survival can be achieved after complete anatomical resection and appropriate neoadjuvant chemotherapy.Hepatoblastoma cases should be referred to specialized centers for management.

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“…The modern era of liver surgery in general did not begin until the 1950s, when Couinaud's description of the segmental nature of the vascular and biliary structure anatomy provided a basis for a logical standard terminology [17][18][19]. Between 1958 and 1988, the mortality rate associated with liver resection declined from 40% to 5% [20][21][22]. Newer surgical refinements now in use are ultrasonic dissection, the water jet and the suction knife, the "hot knife," the harmonic scalpel, and the argon beam laser.…”

Section: Primary Hepatic Tumorsmentioning

confidence: 99%