Major hepatic resection may suppress the growth of tumours remaining in the residual liver

Abstract

Little is known as to how hepatectomy is associated with the growth of hepatic tumours, which may reside in the remaining liver after curative resection for hepatocellular carcinoma. Using an intra-hepatic tumour implantation model in rats, the effects of hepatectomy on tumour growth in the remaining liver were investigated. On post-operative day 7, the tumour weight in the remaining liver following 30% hepatectomy was 0.321 ± 0.058 g (mean ± SD) which was significantly greater than that (0.245 ± 0.040 g) in sham operations (P < 0.05). However, the tumour weight (0.156 ± 0.067 g) in the remaining liver following 60% hepatectomy was significantly lower than that in sham animals (P < 0.005). The number of TdT-mediated dUTP nick-end labelling (TUNEL) positive tumour cells was significantly increased in 60% hepatectomy as compared with the sham and 30% hepatectomy group. The mRNA expression of TGF-β1, TNF-α and Fas in the tumour portion of 60% hepatectomy, was higher than that in 30% hepatectomy group. Plasma levels of TGF-β1 were inversely correlated with intra-hepatic tumour weights. These results suggest that major hepatic resection may lead to an increased induction of apoptosis for the remaining hepatic tumour. © 2000 Cancer Research Campaign

Darbepoetin-α Accelerates Neovascularization and Engraftment of Extrahepatic Colorectal Metastases

“…It was also not clarified whether systemic application of DPO may exert growth stimulation on tumor cells at extrahepatic sites. This, however, is of particular interest, because previous studies have shown that extra- and intrahepatic tumor growth may be differentially influenced by liver regeneration after hepatectomy [28,29]. We herein demonstrate now for the first time that systemic application of DPO also promotes colorectal tumor cell engraftment and growth at extrahepatic sites.…”

Effects of Human Hepatocyte Growth Factor on the Proliferation of Human Hepatocytes and Hepatocellular Carcinoma Cell Lines

“…The restoration of the hepatic volume occurs within 1 week, independent of the hepatic removal volume [27] . Based on this information, we measured the pre-and postoperative serum levels of HGF, EGF, VEGF and TGF-· during 5 days after liver resection.…”

“…This might be explained by the presence of human inhibitory (anti-HGF) factors in the patients' serum. In this context, Yokoyama et al [27] showed that major hepatic resection suppressed the growth of the tumor in the remnant liver. Moreover, major resection caused the expression of apoptosis-related genes and secretion of inhibitory growth factor, such as TGF-ß [27] .…”

Antitumor and antivascular effects of AC-7700, a combretastatin A-4 derivative, against rat liver cancer

“…23 Briefly, AH-130 cells were maintained by intraperitoneal passage in male Donryu rats every 7-8 days. A suspension of AH-130 tumor cells was prepared in Hanks' balanced salt solution (HBSS), at a concentration of 5 ϫ 10 6 cells/ml, and 1 ml was injected into the flank of Donryu rats.…”