Major depressive disorder and depressive symptoms in intermittent explosive disorder

Medeiros, Gustavo C.; Seger, Liliana; Grant, Jon E.; Tavares, Hermano

doi:10.1016/j.psychres.2018.02.001

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…Male aggression towards others may be rooted in evolutionary traits related to fighting, survival and reproduction 34. In addition, testosterone has been found to decrease the amygdala-prefrontal coupling, which may affect emotional processing in males and tend to increase aggression directed towards others 35…”

Section: Discussionmentioning

confidence: 99%

Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury

Medeiros

Seger-Jacob

Garreto

et al. 2019

Braz. J. Psychiatry

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Objective:To investigate the clinical differences between intermittent explosive disorder (IED) (disorder of aggression primarily directed towards others) and nonsuicidal self-injury (NSSI) (disorder of aggression predominantly directed towards the self) in order to better understand the different clinical subtypes of aggression.Methods:We used treatment-seeking samples to compare demographic and clinical correlates between 82 participants with IED and 55 participants with NSSI.Results:The IED group was older, more likely to be male, in a relationship, and employed than the NSSI group. With respect to clinical variables, the NSSI group had more severe depressive symptoms and more social adjustment difficulties. Regarding psychiatric co-morbidities, the IED group had higher rates of generalized anxiety disorder. On the other hand, the NSSI group had higher rates of major depressive disorder, agoraphobia, substance use disorder, and bulimia nervosa.Conclusions:Individuals with NSSI may benefit from better management of psychiatric comorbidities, specifically depressive symptoms and social adjustment difficulties. Conversely, the treatment of individuals with IED may be improved by targeting comorbid generalized anxiety disorder. Our results provide important insight for the development of tailored interventions for specific subtypes of aggression.

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Section: Discussionmentioning

confidence: 99%

Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury

Medeiros

Seger-Jacob

Garreto

et al. 2019

Braz. J. Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Major depressive disorder (MDD) is one of the most prevalent forms of mental disorders that affect millions of individuals worldwide 1 and exerts substantial public health and financial costs to society. Although the symptoms of MDD have been widely acknowledged and recognized by clinicians, 2,3 due to the lack of effective targets for diagnosis and treatment, the incidence rate and mortality rate of MDD increase year by year. 4 Hence, the well understanding of specific molecular mechanisms involved in the development of laryngeal cancer is more urgent and will contribute to identify efficient targets for the diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

<p>MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3</p>

Xue¹,

Zeng²,

Zhu³

et al. 2020

NDT

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Background It is known that miR-532-5p is critical for neuronal differentiation. However, the role of miR-532-5p in depression remains unknown. This study aimed to investigate the role and mechanism of miR-532-5p in major depressive disorder (MDD). Methods The depression mice model was established by chronic unpredictable mild stress (CUMS) and confirmed by forced swimming test (FST) and sucrose preference test (SPT). The role of miR-532-5p in MDD was detected by tail suspension test (TST), FST, SPT and SIT. QRT-PCR was used to detect the expression of miR-139-5p in hippocampus and BV-2 microglia of mice. ELISA and Western blotting were used to detect the expression of the nitric oxide synthase (NOS), proinflammatory cytokines (IL-6, IL-1β, TNF-α, and MCP-1) and transcriptional activator 3 (STAT3). Luciferase reporter assay was used to verify the downstream target genes of miR-532-5p. Results MiR-532-5p was significantly reduced in the hippocampus of mice treated with CUMS. Overexpression of miR-532-5p significantly reduced CUMS-induced depression-like behaviors and suppressed the expression of IL-6, IL-1β, TNF-α and MCP-1. MiR-532-5p directly targeted signal transducers and STAT3 in BV2 cells. In addition, overexpression of miR-532-5p restrained the raise of inducible NOS and IL-6, IL-1 β, TNF-α and MCP-1 in LPS-exposed BV2 cells. Conclusion This study indicates that miR-532-5p plays an important role in CUMS-induced depression-like behaviors by targeting STAT3, and miR-532-5p may be a potential target for MDD therapy.

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“…One factor that has been linked to IED in the general population is depression (Medeiros et al, 2018). For some athletes, the years following the end of professional play have been reported to be emotionally difficult, as athletes are confronted with losses of identity, social relationships, income, and daily routines.…”

Section: Other Relevant Correlates Of Anger Attacksmentioning

confidence: 99%

The Price of Playing Through Pain: The Link Between Physical and Behavioral Health in Former NFL Athletes

et al. 2020

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Over the past decade, media outlets have drawn attention to some of the health consequences of playing in the National Football League (NFL), including how wear-and-tear and injuries accumulated during athletes’ playing years can affect their physical, emotional, and behavioral health after retirement from professional sports. Through a secondary analysis of a cross-sectional telephone survey of former NFL athletes, this study estimated logistic regression models to assess the relationship between several forms of physical pain and anger attacks, controlling for binge drinking, signs of depression, functional limitations, NFL career duration, religious service attendance, and demographic characteristics (age, marital status, race, education, income, and wealth). The analytic sample included 1030 former NFL players. Neck pain, lower back pain, headaches/migraines, and the number of sites of pain were positively and significantly related to anger attacks. There was no significant association between joint pain and anger attacks. NFL career duration was negatively associated with anger attacks, as was religious service attendance. Future research should focus on factors that protect against affective aggression in former professional athletes and how protective factors can be adapted to the broader population.

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Major depressive disorder and depressive symptoms in intermittent explosive disorder

Cited by 6 publications

References 17 publications

Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury

Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury

<p>MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3</p>

The Price of Playing Through Pain: The Link Between Physical and Behavioral Health in Former NFL Athletes

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